SCFAs participate in the pathogenesis of Parkinson’s disease by regulating NLRP3 inflammasomes activation
Objective: To explore the role and related mechanism of gut microbiota metabolites short-chain fatty acids(SCFAs) in the pathogenesis of Parkinson's disease(PD). Background: Growing research have…Multi-modal prognostic biomarkers for Parkinson’s disease progression and severity
Objective: To determine a pathophysiological panel of biomarkers significantly associated with the severity and the disease progression of Parkinson’s disease. Background: Detecting, monitoring and predicting…Dried blood and plasma spots for the measurement of neurofilament light chain and inflammatory cytokines in patients with REM sleep behaviour disorder
Objective: The objective of this study was to investigate the relationship between plasma and dried blood/ plasma spot measurements of inflammatory markers (IFN-ɣ, IL-1β, IL-6,…Genetic correlation and potential causal relationship between inflammatory bowel disease and Parkinson’s disease
Objective: The present study investigates shared genetic etiology between inflammatory bowel disease (IBD) and Parkinson’s disease (PD) using correlation and causality-based approaches. Background: The role…Beneficial effects of cinnamaldehyde in orofacial dyskinesia in haloperidol-induced rat model
Objective: This investigation evaluates the effect of CA in orofacial dyskinesia in haloperidol-induced rat male model Background: Orofacial dyskinesias are involuntary repetitive movements of the…Neurodegeneration and neuroinflammation for biomarker development in MSA
Objective: To investigate the diagnostic and prognostic value of fluid-based and PET imaging biomarkers related to neurodegeneration and neuroinflammation in Multiple System Atrophy (MSA). Background:…Investigating inflammatory mechanisms in iPSC-derived LRRK2 microglia
Objective: To characterize microglial function and inflammatory mechanisms in LRRK2-associated Parkinson’s disease (PD). Background: PD is a neurodegenerative disease affecting primarily dopaminergic neurons of the…PD phenotype with premotor RBD is associated with a dysbiotic profile of gut microbiota.
Objective: The aim of the study was to compare the fecal microbial composition of a group of PD patients with and without premotor RBD. Background:…Dystonic tremor and ataxia as presenting symptoms of multiple sclerosis
Objective: Introduction Tremor in multiple sclerosis (MS) has traditionally been thought to be a feature of advanced disease and pathophysiology of MS tremor is known…The Role Imposed by The High-Mobility Group Box 1 (HMGB1) Protein in MPTP-Induced Zebrafish Model of Parkinson’s Disease
Objective: This study aims to investigate the role of HMGB1 protein in mediating neuroinflammatory-induced parkinsonian movement disorder of the MPTP-induced zebrafish model of Parkinson's disease…
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