7,8- Dihydroxyflavone prevents 3-NitropropionicAcid (3-NP)-induced Striatal Toxicity by Modulating the TrkB receptor and Microglial Activation Pathway
Objective: Hungtion’s disease (HD) is an autosomal governing neurodegenerative disorder caused by production of mutant hungtingtin(Htt) protein followed by death of the GABAergic neurons in…Functional Proteomic Analysis of Leukocytes from Parkinson’s Disease Patients: A Clinical Perspective on Biomarkers Identification
Objective: The aim of this work was to identify proteomic profiles associated with specific Parkinson’s disease (PD) clinical groups in leukocytes of patients from Rio…Evaluating IL6 and mitochondrial DNA levels as a potential biomarker in carriers of Parkin and PINK1 mutations
Objective: To discriminate affected PARK-Parkin and PARK-PINK1 mutation carriers from idiopathic Parkinson’s disease (PD) patients and healthy controls using serum IL-6 and mtDNA levels. Background:…Inflammatory Conditions in Parkinson’s Disease
Objective: The goal was to conduct a case-control study to assess associations between Parkinson disease (PD) and inflammatory conditions including allergies, asthma, eczema, atopic conditions,…Expression profiles from CD14+ monocytes in PD patients with GBA mutations
Objective: To study the pathogenic mechanisms associated with mutations of the GBAgenes in Parkinson’s disease (PD). Background: Mutation of GBA(encoding for glucocerebrosidase, GCase) is one of…Occurrence of brain capillary dysfunction in patients with REM sleep behavior disorder
Objective: To assess whether changes in brain capillary function measured with magnetic resonance imaging (MRI) can be detected in patients with REM sleep behavior disorder…Balance training modulates the concentration of pro- and anti-inflammatory cytokines in the plasma of elder people and PD patients. A pilot study
Objective: Assessment as to whether moderate intensity systematic balance training (BT) affects the level of IL-10, IL-6 and TNF-α in healthy, elder people and in…18F-DPA714 PET reveals neuroinflammatory activity in the Substantia nigra of patients with Parkinson disease
Objective: We investigated whether 18F-DPA714 imaging could be a sensitive marker of neuroinflammation in Parkinson disease (PD). We took into account the polymorphism of TSPO…Inflammatory cytokines in Saudi Parkinson cohort
Objective: To identify inflammatory diagnostic and prognostic biomarkers for PD in serum. Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's…Cortical cholinergic dysfunction correlates with microglial activation in the Substantia Innominata in patients with REM sleep behavior disorder
Objective: To explore possible correlations between levels of microglial activation (neuroinflammation) in the Substantia Innominata (SI), the major source of cholinergic input to the cortex,…
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