Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…Lymphocytes have a detrimental effect on motor behavior in the AAV1/2 A53T α-synuclein mouse model of Parkinson’s disease
Objective: To determine the contribution of the adaptive immune system in the pathogenesis of a mouse model of Parkinson's disease (PD) based on AAV1/2 driven…Involvement of peripheral immune system in the pathogenesis of Parkinson’s disease
Objective: To investigate the role of peripheral immune system in the pathogenesis of Parkinson's disease carrying LRRK2 risk variants. Background: Leucine-rich repeat kinase 2 (LRRK2)…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Associations between cerebrospinal fluid proteins and cytokines in Parkinson’s disease
Objective: To investigate the relationship between cerebrospinal fluid (CSF) proteins and cytokines, and their correlation with clinical measures in PD. Background: Several studies have investigated…Effectiveness and micro-electrodes findings of deep brain stimulation of the STN via a parietal approach in post-infectious previously implanted Parkinson´s patients
Objective: To report our experience with an alternative entry point to access STN in the treatment of Parkinson's disease (PD) and its micro-electrodes findings. Background:…The effects of viral priming on neurotoxin induced neurodegeneration and synapse dysfunction in cell culture models relevant to Parkinson’s disease
Objective: To investigate the effects of viral innate immune activation on neurodegeneration and synaptic protein expression in dopaminergic (DA)-like neurons following treatment with Parkinson's disease…Treatment of lipopolysaccharide-induced parkinsonism
Objective: This single case report of levodopa-responsive parkinsonism, caused by an accidental systemic contamination with 10 microgram lipopolysaccharides (LPS) from Salmonella minnesota, describes the treatment…DJ-1 regulates intracellular signaling in a highly cell type specific manner
Objective: To evaluate a cell type specific action of DJ-1, a PD and cancer associated gene, in intracellular signaling pathways. Background: Understanding the pathophysiology of…Targeting TLR4 for disease modification in multiple system atrophy: Experimental evidence
Objective: To assess the efficacy of toll-like receptor 4(TLR4) agonists to ameliorate the functional and neuropathological phenotype of a transgenic mouse model of multiple system…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.