A panel of CSF and plasma biomarkers reveals novel biological insights into atypical parkinsonian syndromes
Objective: Our study aims to identify diagnostic markers of atypical parkinsonian disorders that offer novel insights into these conditions. In particular, we wish to use…Peripheral Inflammatory Mediators in Parkinson’s Disease – A Potential Biomarker
Objective: i.To determine if post-translationally modified phosphorylated α-synuclein levels are altered in the peripheral blood of Parkinson’s disease (PD) patients compared to control subjects. ii.To…Evidence for dysregulation of inflammatory mechanisms involving the NF-κB complex in the living parkinsonian brain
Objective: Sequence RNA in cortical samples taken from living PD patients to detect significant differentially expressed genes (DEGs) and altered biological pathways when compared to…Dural lymphatic vasculature in human superior saggital sinus: the brain drain
Objective: To provide independent validation in human dura obtained at autopsy of the reported presence of dural lymphatic vessels. Background: Two recent studies have challenged…Evaluation of CSF cytokine profiles in people with Parkinson disease and age-matched controls.
Objective: To investigate the levels of cytokines in the cerebrospinal fluid of subjects with Parkinson disease (PD) and matched healthy controls. Background: Neuroinflammation is thought…[11C]PK11195 PET Imaging Reveals Neuroinflammation in Dementia with Lewy Bodies: NIMROD Study
Objective: To determine if subjects with dementia with Lewy bodies(DLB) have increased microglial activation in vivo compared to matched healthy controls as assessed using PET…Meta-analysis of the interaction between HLA-DRB1 and smoking with Parkinson’s disease
Objective: To investigate interactions between HLA-DRB1 rs660895 polymorphisms and smoking in PD using meta-analysis to pool data from three large population-based studies. Background: Inflammatory response…Expression of OX40 and OX40 serum level in patients with Parkinson’s disease
Objective: Study the expression of OX40 gene and its serum levels could be measured to predict and confirm diagnosis of Parkinson's disease and help develop new…Expanding the spectrum of Faciobrachial Dystonic Seizures
Objective: A 71 years old Italian man presented progressive dysarthria and involuntary movements. Background: Within two months he developed dysarthria, progressive homolateral oromandibular and arm dystonic posture, knee…A PSP-like phenotype accompanies rapidly progressive dementia
Objective: We describe a patient with a progressive supranuclear palsy (PSP)-like phenotype and a rapidly progressive dementia, who was found to have an unknown CSF…
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