Inhibiting sphingosine-1-phosphate lyase as a possible therapy in Huntington’s disease
Objective: To advance our understanding of the process by which the mutant huntingtin (mHTT) protein contributes to neurodegeneration and translate that knowledge to potentially effective disease…Evidence of putaminal petechial hemorrhage as the cause of hyperglycemic chorea
Objective: To report a series of magnetic resonance image (MRI) study and advise the initial putaminal petechial hemorrhage following with gliosis as the cause of…Salivary biomarkers for Huntington’s disease (HD)
Objective: The objective of the current study was to assess the potential for saliva to serve as a biospecimen for accessible biomarkers for Huntington’s disease…Dynamic prediction of motor diagnosis in Huntington’s disease using a joint modeling approach
Objective: Compare various clinical and biomarker trajectories for tracking Huntington's disease (HD) progression and predicting motor conversion. Background: Huntington’s disease (HD) is a fatal neurodegenerative disease…Loss of PDE10A expression in patients with PDE10A and ADYC5 mutations
Objective: To assess phosphodiesterase 10A (PDE10A) expression in vivo, using [11C]IMA107 PET in patients with PDE10A and adenylate cyclase 5 (ADYC5) mutations. Background: Cyclic adenosine…The Long-Term Safety of Deutetrabenazine for Chorea in Huntington Disease
Objective: To evaluate the safety and tolerability of deutetrabenazine in Huntington Disease (HD) over long term exposure. Background: In a randomized, double-blind, controlled trial (First-HD),…Clinical and genetic characterization of Huntington’s disease in relation to the age and type of onset.
Objective: To describe the clinical features and CAG repeats in a large population of Mexican patients with Huntington's disease and its relation to the age…Long-Term Dopamine Transporter Imaging and Clinical Effects of the Mixed-Lineage Kinase Inhibitor CEP-1347 in the PRECEPT Parkinson Trial
Objective: To assess the imaging and clinical effects of CEP-1347 after treatment discontinuation in the Parkinson Research Examination of CEP-1347 Trial (PRECEPT), a multi-center randomized…The Huntington’s Disease Health Index Study (HD-HI)
Objective: To identify the symptomatic domains with the greatest impact on quality-of-life for those living with Huntington’s Disease (HD) through patient and caregiver interviews. Background:…Prescription pattern of treatment in Mexican patients with Huntington’s Disease.
Objective: To describe the prescription pattern for the treatment of HD in a sample of Mexican patients from a tertiary referral center. Background: Huntington’s disease…
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