The shared risk of apolipoprotein E ɛ4-allele on hippocampal volume across the spectrum of Alzheimer’s disease and dementia with Lewy bodies: Evidence from the Sunnybrook Dementia Study
Objective: To identify the association of apolipoprotein E ɛ4-allele (APOE-ε4) with hippocampal volumes across the spectrum of Alzheimer’s disease (AD) and dementia with Lewy bodies…Association between MAPT haplotype and hippocampal repetition suppression in Parkinson’s disease
Objective: We aimed to explore the relationship between the microtubule-associated tau gene (MAPT) haplotypes and response in the hippocampus to repeated stimuli in Parkinson’s disease…Relationships between specific subtypes of mild cognitive impairment and grey matter atrophy in Parkinson’s disease
Objective: Our aim was to investigate grey matter (GM) atrophy patterns in Parkinson’s disease patients with normal cognation (PD-NC) or with mild cognitive impairment（PD-MCI）using voxel…Cholinergic basal forebrain and hippocampal structure influence visuospatial function in Parkinson’s disease
Objective: To assess relationships between the structural status of the cholinergic basal forebrain (cBF), hippocampus (HPC) and multi-domain cognitive function in Parkinson’s disease (PD). Background:…Microglial activation, white matter and hippocampal damage correlate with cognitive impairment in chronic cerebral hypoperfused and MPTP-lesioned mice
Objective: We hypothesize that cerebral hypoperfusion may influence the cognitive function of PD animal models. To investigate the effects of cerebral hypoperfusion and microangiopathy on…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…Increased hippocampal activation in Parkinson’s disease related amnestic mild cognitive impairment
Objective: To assess the functional significance of hippocampal network dysfunction in Parkinson’s disease related amnestic mild cognitive impairment (PD aMCI) using high-resolution functional neuroimaging. Background:…Impaired hippocampal neurogenesis associates with serotonergic axonal degeneration in transgenic rat and mouse models of Parkinson’s disease
Objective: To evaluate the impact of α-synuclein accumulation on the hippocampal serotonergic system and hippocampal plasticity in two different α-synuclein expressing rodent models. Background: Parkinson's…Differential expression of cerebral dopamine neurotrophic factor (CDNF) in the hippocampus and in the striatum of LRRK-2 mutant rat model of Parkinson’s disease
Objective: The objective of our study was to characterize the behavioral phenotype of the transgenic LRRK-2 rat in the context of PD model and to…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.