Electrophysiological correlates of neurological deficits in toxic-metabolic encephalopathy
Objective: We used transcranial magnetic stimulation (TMS) paradigms reflecting GABAA, GABAB, cholinergic and glutamatergic transmission at the motor cortex level, to investigate pathophysiology of different…Changes in GABAergic transmission of striatal neurons in presymptomatic Huntington’s Disease
Objective: To determine whether parameters of synaptic and extrasynaptic GABAergic inhibition of striatal projection neurons are altered in presymptomatic BACHD mice. Background: One attractive early…GABA-A Receptor Positive Allosteric Modulators: Phase 2 Proof of Concept Studies of Brexanolone Injection and SAGE-217 in Essential Tremor
Objective: To examine use of γ-aminobutyric acid (GABA) type A receptor (GABA-A-R) positive allosteric modulators (PAMs) in the treatment of essential tremor (ET) in early…Activity of Neurosteroid GABAA Positive Allosteric Modulators in Preclinical Harmaline Model for Essential Tremor
Objective: The objective of the present study was to test the activity of neurosteroid (NAS) GABAA positive allosteric modulators, including novel synthetic NAS SGE-516, at…A Case of Pregabalin induced Parkinsonism
Objective: Present a case of parkinsonism after administration of pregabalin, a rare case Background: Drug induced parkinsonism is the second common movement disorders after Parkinson’s…Ocular motor function in stiff person syndrome – Role of GABA and beyond
Objective: Delineate pathophysiology of gaze-holding function in stiff person syndrome (SPS). Background: Glutamic acid decarboxylase (GAD) catalyzes conversion of glutamate to gamma-aminobutyric acid (GABA). Anti-GAD…Intrathecal baclofen (ITB) therapy in the treatment of severe spasticity: Safety and Product Performance from a Large Multinational Multi-Center Registry
Objective: •To use real-world registry data to augment available safety data, product performance and support overall efficacy. •To utilize registry data to broaden awareness of…Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats
Objective: (1) Curcumin is well tolerated curcuminoid used as supplement for various disorders but problem is its low oral bioavailability. (2) Piperine is combined to…Cerebellar GABA-A receptor activity is inversely correlated with gait speed in Parkinson’s disease
Objective: To investigate the relationship between regional cerebral expression of benzodiazepine receptors and gait speed in Parkinson's disease (PD). Background: Flumazenil is a short-acting intravenously…Dopaminergic medication affects choice bias in Parkinson’s disease
Objective: Assess dopaminergic effects on choice bias in Parkinson's disease (PD). Background: Bradykinesia, rigidity and resting tremor are the core symptoms of PD, but many…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.