SAGE-324/BIIB124, an investigational GABAA receptor PAM, for treatment of essential tremor
Objective: KINETIC2 is a multicenter, randomized, placebo-controlled, dose-response Ph2b study evaluating SAGE-324/BIIB124 for treatment of essential tremor (ET). Background: ET is a common movement disorder1,2…Understanding the Neurochemical Basis of STN and GPi-DBS: A Human Microdialysis Study
Objective: Analyze the extracellular concentrations of GABA and glutamate in response to acute electrical stimulation during DBS surgery using samples obtained from STN, thalamus, GPi…A Phase IIb Double-Blind Placebo-Controlled Randomized Cross-Over Clinical Trial of Sodium Oxybate in Isolated Focal Laryngeal Dystonia
Objective: A phase IIb double-blind, placebo-controlled, cross-over, randomized clinical trial of a single dose of sodium oxybate investigated the efficacy and safety of the drug…GABA in the Basal Ganglia Tracks Motor Severity and Response to BoNT Treatment in Cervical Dystonia
Objective: Determine if GABA and glutamate levels within sensorimotor network nodes correlate with symptom severity in cervical dystonia (CD) and are altered by botulinum neurotoxin…Abnormal brain iron metabolism influences neural function in isolated laryngeal dystonia
Objective: To investigate iron accumulation as a pathophysiological signature of laryngeal dystonia (LD) and assess the abnormal influence of iron on neural activity within the…Ionic Plasticity of Midbrain GABAergic Synapses in PD Models
Objective: To validate that enhancing potassium-chloride cotransporter activity would restore inhibition and normal function in parkinsonian Substantia nigra reticulata (SNr) and participate to Parkinson’s disease (PD) symptom alleviation. Background: The SNr is an output nucleus…Axon terminal hypertrophy of striatal projection neurons with levodopa-induced dyskinesia priming
Objective: We examined whether levodopa-induced dyskinesia (LID) and axon terminal hypertrophy gradually develop with repeated levodopa treatment in Parkinsonian rats to prove that the hypertrophy…KINETIC 2: An ongoing phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor
Objective: KINETIC 2 (NCT05173012) is an ongoing, phase 2b, randomized, double-blind, placebo-controlled, dose-response study that aims to evaluate the efficacy, safety, and tolerability of SAGE-324/BIIB124…Cerebral Topography of [11C]-Flumazenil GABAA Receptor Expression in Parkinson’s Disease Fallers and Freezers
Objective: To examine the cerebral topography of GABAA Receptor Expression in Parkinson’s Disease (PD) Fallers and Freezers. Background: Episodic mobility disturbances, like falls and freezing…Electrophysiological correlates of neurological deficits in toxic-metabolic encephalopathy
Objective: We used transcranial magnetic stimulation (TMS) paradigms reflecting GABAA, GABAB, cholinergic and glutamatergic transmission at the motor cortex level, to investigate pathophysiology of different…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.