Free water neuro-imaging changes as the biomarker in new diagnosis of Wilson’s disease
Objective: The bi-tensor free water imaging may provide more specific information in detecting microstructural brain tissue alterations than conventional single tensor diffusion tensor imaging. The…Neuroprotective effects of estradiol and progesterone in brain of different age groups of naturally menopausal rats.: A therapeutic potential drug for Parkinson’s disease
Objective: The objective of this study was to determine the effect of E2 and P4 on the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), oxidative stress…Role of Uric Acid in Friedreich Ataxia neurodegeneration
Objective: Friedreich Ataxia (FRDA) is an inherited recessive disease with reduced frataxin levels. This causes a reduced mitochondrial function and progressive neurodegeneration. The aim of…Copper induced neurobehavioral features of Parkinson’s disease and oxidative stress and their abatement by Eugenol
Objective: The aim of this study was to evaluate impact of copper intoxication (10 mg/kg B.W) for 3 days on locomotor performance and oxidative status,…Vitamin D assessment in patents with Parkinson’s disease
Objective: Analysis of the effectiveness of vitamin D in patients with PD depending on clinical manifestations and concentration levels of 25 (OH) D. Background: Recent…Metabolomic Profiling of Activated Microglial Cells
Objective: To investigate metabolomic changes in SIM-A9 microglia in vitro following exposure to neuroinflammatory insult using high resolution mass spectrometry. Background: Microglial cells play an…MitoQ and Reduced Glutathione Protects Against Dopamine Induced Brain Mitochondrial Electron Transport Chain Inhibition During Extended In Vitro Incubation: Involvement of Free Radicals and Quinone Products
Objective: To study the impact of MitoQ and GSH against DA induced rat brain mitochondrial electron transport chain inhibition during extended in vitro incubation. Background:…Levodopa, placebo and rotigotine change biomarker levels for oxidative stress
Objective: The objective was to investigate the influence of the D1 receptor agonists levodopa and rotigotine compared with placebo on homocysteine and cysteinyl-glycine in plasma…