Hyperkinetic Movement Disorder as the First Manifestation of Gaucher Disease Type 3
Objective: Gaucher disease, an autosomal recessive lysosomal storage disorder, is caused by a deficiency of the enzyme glucocerebrosidase. This results in the accumulation of glucosylceramide…Associations Between Saccadic and Motoric Symptoms in Parkinson’s Disease
Objective: To explore associations between saccadic measures and i) global motor, ii) non-tremor motor, and iii) tremor severity in Parkinson’s disease (PD). Background: Impaired voluntary…Saccadic Hypometria as a Biomarker of Longitudinal Change in MDS-UPDRS Part II and Axial Motor Subscores: Results from the Multicenter PALOMA Trial
Objective: To evaluate the relationship between longitudinal changes in saccadic hypometria and changes of clinically meaningful outcomes, specifically axial impairment and MDS-UPDRS Part II scores,…Relationship between automatic analysis of gait disorder and eye movement capture by AI and cognitive function in Parkinson’s disease
Objective: Gait disorder is a hallmark of Parkinson’s disease (PD), with mounting evidence linking gait to cognitive function in PD patients and eye movements serving…Eye tracking identifies biomarkers predicting Parkinson’s disease before motor symptom onset
Objective: To investigate eye movement changes as an early motor biomarker of Parkinson’s disease (PD) in patients with REM sleep behavior disorder (RBD). Background: RBD…Resolution Dependence of Machine Learning for Differential Diagnosis of Parkinsonian Eye Movements
Objective: To establish the extent to which high temporal resolution is required to differentiate between parkinsonian disease states from eye movements. Background: Previous studies have…Digital measurement of ocular microtremor in Parkinson’s Disease: Analytical and clinical validation
Objective: This pilot study examined the analytical and clinical validation of OMT measurement via the iTremor ONE device in PwPD. Background: Ocular microtremor (OMT) is…Machine Learning Model using Eye Movements for the Differential Diagnosis of iPD and Atypical Parkinsonian Syndromes
Objective: To develop a machine learning (ML) model to first between differentiate between healthy controls, idiopathic PD, Atypical Parkinsonian syndromes and then further subclassify as…Oculomotor Differences in PARK2 PD: a Study of Structured and Unstructured Eye Movements in an Irish Genetic Cohort
Objective: To identify and measure how eye movements differ between biallelic PARK2 carriers, carriers of a single PARK2 variant and non-carriers using structured and unstructured…Concomitant Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis Versus Motoneuron Phenotype of PSP in Ukrainian Patient
Objective: To provide a description of a rare case of mixed progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) in Ukrainian patient. Background: The…
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