An Open-Label, Phase 1b Study of the Neuroactive Steroid GABAA Receptor Positive Allosteric Modulator SAGE-324 in Essential Tremor
Objective: This single dose, open-label, Phase 1b study assessed the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SAGE-324 in otherwise healthy patients with Essential…Cortical network fingerprint and prediction of deep brain stimulation-induced speech impairment in essential tremor
Objective: To gain insights into brain areas associated with stimulation-induced dysarthria (SID) and to predict stimulation-induced worsening of intelligibility in essential tremor (ET) patient with…Efficacy and safety of CX-8998 in T-CALM, a randomized, double-blind, placebo-controlled, phase 2a trial in participants with essential tremor: subgroup analysis by baseline tremor severity
Objective: Evaluate efficacy and safety of CX-8998 in essential tremor (ET) as a function of baseline tremor severity. Background: CX-8998, a selective modulator of T-type…Quantitative Tremor Analysis of Functional Tremor
Objective: To compare the characteristic frequency of functional tremor with other tremor disorders using 3-D motion analysis and kinematics. Background: Functional tremor (FT) is a…Clinical and etiological aspects of movement disorders in a low-income country: Case of Mali
Objective: Describing Clinical and etiological aspects of movement disorders in Mali Background: Movement disorders (MD) correspond to a disturbance in the programming and / or…Quality of life in ET and ET-plus patients with thalamic deep brain stimulation
Objective: To compare the quality of life (QOL) and activities of daily living (ADL) of patients with Essential Tremor (ET) and Essential Tremor plus (ET-p)…Altered Spontaneous Brain Activity in Essential Tremor with and without Resting Tremor: A Resting-state fMRI Study
Objective: This study aims to use resting-state functional magnetic resonance imaging (rs-fMRI) to explore the alterations of brain activity in drug-naïve patients with Essential tremor…Direct Targeting of the VIM Nucleus during High Intensity Focused Ultrasound (HIFU) by Direct Visualization
Objective: To determine the “functional” target within VIM Nucleus of the Thalamus during HIFU with high field MRI. Background: Targeting of neuronal structures has been…Large-Scale Network Changes in the Pathophysiology of Essential Tremor
Objective: To assess functional brain network architecture in participants with medically-refractory essential tremor (ET) and to correlate the strength of these networks with clinical tremor…A Case Series Highlighting Non-Traditional Movement Disorder Candidates for Deep Brain Stimulation Therapy Who Benefited Positively
Objective: This case series was designed to highlight non-traditional patients with movement disorders who received Deep Brain Stimulation (DBS) and benefitted from therapy, in an…
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