KINETIC 2: An ongoing phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor
Objective: KINETIC 2 (NCT05173012) is an ongoing, phase 2b, randomized, double-blind, placebo-controlled, dose-response study that aims to evaluate the efficacy, safety, and tolerability of SAGE-324/BIIB124…Success of MRI-guided focused ultrasound thalamotomy after failure of Gamma Knife radiosurgery for essential tremor
Objective: To study the effect of MR-guided focused ultrasound (MRgFUS) targeting the ventral intermediate nucleus of the thalamus (VIM) after a failed ipsilateral Gamma Knife…Structural MRI and tremor analysis in the differential diagnosis of rest tremor
Objective: This study aimed to differentiate between essential tremor with rest tremor (rET) and tremor-dominant Parkinson’s disease (td-PD) patients through a machine learning (ML) approach…Serum neurofilament light-chain concentrations in essential tremor: A case-control study
Objective: We sought to investigate the concentrations of serum neurofilament light-chain (NfL) in essential tremor (ET) patients and healthy controls. Background: Essential tremor is a…Tremor Reduction Using DBS: Outcomes of a Real-world, Prospective, Multicenter Essential Tremor Registry
Objective: In this report, preliminary data will be presented from a prospective, multicenter, international Essential Tremor (ET) outcomes study in which patients received a multiple…Active contact proximity to the CTT predicts initial therapeutic current requirement in DBS for ET: an application of 7T MRI
Objective: We sought to characterize the impact of deep brain stimulation (DBS) active contact location relative to the cerebellothalamic tract (CTT) on stimulation parameters in…The spatial and spectral organization of thalamo-cortical connectivity in patients with essential tremor
Objective: To identify cortical areas coupled to the ventral intermediate nucleus of the thalamus (VIM) in patients with essential tremor (ET). Background: ET is a…Late onset cerebellar ataxia in patients treated with VIM DBS
Objective: To highlight the predictors for onset of cerebellar ataxia in patients treated with deep brain stimulation (DBS) of the Thalamic Ventral Intermediate Nucleus (VIM)…Accelerometric Classification of Resting and Postural Tremor in Essential Tremor and Parkinson’s Disease
Objective: To investigate the predictive value of different accelerometry metrics for clinical ratings of Essential Tremor (ET) and tremor in Parkinson’s Disease (PD). Background: To…Spiral drawing features are similar between essential tremor and essential tremor plus
Objective: To explore the features on free hand spirals drawn by patients with essential tremor and essential tremor plus. Background: The 2018 consensus statement on…
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