Rare Observations of Sustained Symptomatic Improvement with Botulinum Toxin Type A Injections in Facial and Cervical Dystonia: Case Series
Objective: To describe prolonged improvement in patients with involuntary facial and cervical movements after BTX-A therapy. Background: Botulinum toxin type A (BTX-A) treatment is considered…Muscarinic receptor antagonism beyond M4 is required for efficacy in a preclinical model of dystonia and Parkinson’s disease
Objective: To inform the target activity profile of future movement disorder therapies, pre-clinical studies quantified the contribution of M4 receptor occupancy (M4RO) to reversal of…Challenges in Airway Management after Deep Brain Stimulation in DYT1 Dystonia: a Case Report
Objective: To highlight the challenges in upper airway management following deep brain stimulation (DBS) in patients with severe, medically refractory DYT1 dystonia and to emphasize…Adherence with Digital Outcome Measures in Focal Dystonias
Objective: We assessed patient adherence with an app-based patient-centered outcome (PCO) tool for focal dystonia in a prospective study to determine the impact of dystonia…Long-Term Therapeutic Effect of Botulinum Neurotoxin Type A (BoNT-A) in Cervical Dystonia: A Case Series.
Objective: To evaluate the long-term therapeutic effect of Botulinum neurotoxin type A (BoNT-A) in cervical dystonia. Background: Cervical dystonia is the most common adult-onset focal…National Survey of DYT/PARK-GCH1 (Segawa Disease) in Japan
Objective: To clarify clinical features of Segawa Disease (SD) in Japan. Background: Prof Segawa discovered SD 50 years ago, and GCH-1 gene mutations were linked…GPi-DBS responsive laryngeal dystonia in SGCE myoclonus-dystonia
Objective: To describe a case of DBS-responsive laryngeal dystonia in the setting of myoclonus-dystonia secondary to e-sarcoglycan (SGCE) mutation. Background: DBS is emerging as a…The Vodka Trial: Clinical and Genetic Characteristics of Alcohol Responsiveness in Laryngeal Dystonia
Objective: To determine the objective characteristics of alcohol responsiveness in laryngeal dystonia (LD) using a standardized alcohol challenge test and genetic testing. Background: LD is…Development and Testing of a Smartphone Application to Capture Patient-Centered Outcome (PCO) Measures for Dystonia
Objective: Develop a smartphone application to collect patient-centered outcome (PCO) measures for dystonia. Background: PCO measures tailored for each major adult-onset focal dystonia subtype (Cervical…Understanding Family and Clinician Perspectives on Treatment Decision-Making for Acute Dystonia Exacerbations in Children
Objective: Primary: To identify factors influencing the decision to provide acute pharmacological treatment for dystonia exacerbations in hospitalized pediatric patients. Secondary: To assess the alignment…
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