Neural Signals in the Cerebellar Nuclei Gate the Manifestation of Dystonia-Associated Symptoms in Mice
Objective: Define the differences in electrophysiological signatures of cerebellar output between mouse models of dystonia with diverse severity and manifestation. Background: Dystonia is heterogeneous movement…Distinct patterns of dyskinetic and dystonic features following D1 or D2 receptor stimulation in a mouse model of parkinsonism
Objective: We set out to compare patterns of dyskinetic behaviours induced by the systemic administration of L-DOPA and D1 or D2 receptor (D1R, D2R) agonists…Surround inhibition (SI) in the human motor system during real life motor tasks.
Objective: To assess motor SI during real life motor tasks. Background: SI is a neurophysiological mechanism in the human nervous system that focuses neuronal activity…Promising Biomarkers for Task Specific Dystonia
Objective: To test the sensitivity, specificity, reproducibility and reliability of two neurophysiologic variables using transcranial magnetic stimulation (TMS) as potential diagnostic biomarkers of task specific…Pallidal recordings in fully implanted dystonic patients: preliminary results
Objective: To describe oscillatory patterns of pallidal local field potentials (LFP) in fully implanted patients with dystonia. Background: New implantable devices for deep brain stimulation…Subcortical spectral perturbations during foot movements in PD patients with and without dystonia
Objective: To investigate subcortical brain oscillations at rest and during contralateral foot movements in PD patients with and without dystonia. Background: Dystonia is a painful,…A study of microstructural changes and functional connectivity in cranial, cervical, and cranio-cervical segmental dystonia by multimodal MRI
Objective: To study the microstructural changes and functional connectivity in cranial, cervical, and cranio-cervical segmental dystonia using voxel-based morphometry (VBM), diffusion tensor imaging (DTI), and…Characterizing the temporal discrimination threshold in musician’s dystonia
Objective: To compare the temporal discrimination threshold (TDT) between musician's dystonia (MD) patients, healthy musicians and non-musician controls. Background: MD is a focal, task specific…Exploring Local Field Potential changes in Dystonic Camptocormia.
Objective: To describe a novel technology for detection of local field potentials in bilateral GPi-DBS to identify local field potential biomarker changes in dystonic camptocormia.…Dystonic tremor and ataxia as presenting symptoms of multiple sclerosis
Objective: Introduction Tremor in multiple sclerosis (MS) has traditionally been thought to be a feature of advanced disease and pathophysiology of MS tremor is known…
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