MEK inhibitors have antidyskinetic effects in hemiParkinsonian rats that are associated with critical neurochemical alterations in the striatum
Objective: To examine the effects of MEK inhibitors PD98059 and U0126 on L-DOPA-induced dyskinesia and the induced molecular changes. Background: L-DOPA-induced dyskinesia (LID) represents one…AntiParkinsonian effects of the “radiprodil and tozadenant” combination in MPTP-treated marmosets
Objective: Investigate a combination of two clinically tested drugs, the NR2B antagonist Radiprodil and the A2A antagonist Tozadenant in unilaterally 6-OHDA-lesioned rats and in MPTP-treated…Bilateral subthalamic nucleus deep-brain stimulation (STN-DBS) in the management of idiopathic Parkinson’s disease: Results of our first 20 cases
Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely accepted as a treatment for advanced Parkinson's disease (PD). However, published studies were…Monitoring dyskinesia severity using wearable sensor data
Objective: Herein we present the results of ongoing work focused on estimating limb-specific dyskinesia in patients with PD using wearable sensor data collected in the…Selective M4 antagonism potentiates L-DOPA-induced dyskinesia in MPTP-treated common marmosets
Objective: To determine the role of M4 muscarinic receptors in the expression of L-DOPA-induced dyskinesia (LID) and dystonia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated common marmosets. Background:…Stereotactic pallidotomy for Parkinson’s disease in El Salvador: One year follow up
Objective: Characterize patients with idiopathic Parkinson's disease undergoing posteroventral pallidotomy. Assess improvement in motor symptoms after pallidotomy. Background: Parkinson's disease is a neurodegenerative disease with…Automated assessment of advanced motor Parkinson’s disease; a pilot study of the Parkinson’s KinetiGraph as an objective tool for measurement of motor fluctuations
Objective: To evaluate the utility of the Parkinson's KinetiGraph (PKG) as a tool in advanced Parkinson's disease (PD) to determine need for treatment change by…Hemi-stereotypies symptomatic to aneurysm: Differential diagnosis of tardive dyskinesia
Objective: Below we present the case of a hemi-stereotypies symptomatic to aneurysm of the middle cerebral artery presented in mass effect on the subthalamic nucleus…A national case study of virtual care visits for Parkinson’s disease (RACE-PD): Interim assessment of participant and investigator experiences
Objective: RACE-PD is a case series that aims to assess the feasibility and utility of a national program providing individuals with Parkinson's disease (PD) a…“Two odd targets” strategy in deep brain stimulation for Parkinson’s disease with unilateral dystonia
Objective: To describe a patient underwent deep brain stimulation (DBS) with different target in left and right. Background: DBS is a therapeutic option for movement…
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