The highly-selective metabotropic glutamate receptor 2 positive allosteric modulator LY-487,379 alleviates psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset
Objective: To investigate the effect of metabotropic glutamate receptor 2 (mGluR2) activation on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced psychosis-like behaviours (PLBs) and dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset…Design and personalisation of new upper-limb dynamic orthoses for dystonia and dyskinesia
Objective: The study proposes a method to obtain anatomically- and functionally-personalised orthotics for the dynamic postural control of the upper limb. Background: The orthotic treatment…Is there a significant relationship between weight loss and prevalence of side effects of Parkinsonian medication? A retrospective, single-centre analysis, South Wales, UK.
Objective: To investigate if there is a significant relationship between weight loss in persons with Parkinson’s disease and side-effect incidence, and if so to what…Tremor as the first symptom reported by Parkinson’s disease patients is a predictor of future motor subtype and levodopa-induced dyskinesia.
Objective: To better delineate risk profiles for the development of levodopa-induced dyskinesia is an important effort that can help understand this phenomenon and could impact…Tremor-Dominant Clinical Phenotype is Associated with Low Risk of Levodopa-Induced Dyskinesia in Parkinson’s Disease
Objective: To evaluate possible associations between epidemiological and clinical data with risk of levodopa-induced dyskinesias (LID) onset in Parkinson’s disease (PD) patients. Background: LID are…Wearable sensor-based therapy titration for Parkinson’s Disease
Objective: To describe a home-based method for improved Parkinson’s therapy titration. Background: Many patients with Parkinson’s disease, due to the location of their residence or…Association of Single Nucleotide Polymorphism in MAOB and Risk of Levodopa-Induced Dyskinesias in Parkinson’s Disease
Objective: To identify genetic risk factors for developing levodopa-induced dyskinesias (LID) in patients with Parkinson’s disease (PD). Background: LID are common complications in PD, but…Cause-Specific Hazard of Motor and Nonmotor Long Term Complications of Idiopathic Parkinson’s Disease in a Hospital-based Outpatient Clinic Incident Cohort of 1333 Patients
Objective: To compare the relative incidence rates, at identical disease duration, of motor and nonmotor clinical milestones in the long-term disease course of Parkinson’s disease…Final validation of an electronic diary for motor fluctuations and dyskinesias evaluation in PD patients: Comparison with paperback diary.
Objective: To determine the reliability and compliance to an electronic motor diary in PD patients. Background: Despite paper diaries are widely used, adherence, duplication, fraudulent…Genetic variants influencing dyskinesia; potential consequences for treatment in Parkinson’s disease
Objective: To examine the association between dyskinesia and haplotypes in the genes of three dopamine receptors (DRD1, DRD2 and DRD3) and of the Brain Derived…
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