The interplay between asymmetric dopaminergic degeneration, brain structural changes and cognition in de-novo PD: The PPMI dataset
Objective: To characterize the impact of asymmetric dopaminergic degeneration, measured with I123-ioflupane SPECT (DATSCAN), on cortical integrity and cognitive deficits, in de-novo right-handed PD patients.…TET2-mediated Cdkn2A DNA hydroxymethylation in dopaminergic neuronal injury of Parkinson’s disease
Objective: Studies have shown that 5-hmC modification is the reverse reaction of DNA methylation, and that this process is regulated by TET family hydroxylases, but…Auxilin knockout mice: a model for Parkinsonism with dopamine dysregulation and synucleinopathy
Objective: To evaluate the role of auxilin in the pathogenesis of Parkinson’s disease (PD). Background: Auxilin or DNAJC6, a brain-specific co-chaperone plays central role in…Effects of exosomes devised from dopaminergic neurons overexpressing α-synuclein on autophagy and inflammation in microglia
Objective: The aim of this study was to investigate whether the exosomes secreted by dopaminergic neurons over-expressing α-synuclein could regulate the inflammation of microglia via…L-DOPA treatment in N2a cells stimulates neuromelanin biosynthesis: Using a novel in vitro model to examine the effect of iron and light on neuromelanin production
Objective: Naturally-occuring quantities of in vivo neuromelanin (NM) are low, and the collection of NM from tissue involves laborious extraction and isolation. Thus, in vitro…The Influence of 3-Phenoxybenzoic Acid in Dopaminergic Degeneration
Objective: 3-phenoxybenzoic acid (3-PBA) is a metabolite of Fenpropathrin (FEN). The emphasis of this paper is on the relationship between 3-PBA and Dopaminergic Degeneration. Background:…Neuroprotective effect of Yerba mate (Ilex paraguariensis) in a Drosophila model of Parkinson ’s disease
Objective: To test the neuroprotective capacity of Yerba Mate (YM) in an in vivo model of Parkinson's disease. Background: Parkinson's disease (PD) is caused by the…Assessment of neuronal morphology to determine the differential susceptibility to Parkinson’s disease using MPTP in two genetically distinct mice strains
Objective: To delineate the contribution of neuronal-dendritic structure in the substantia nigra and striatum, in conferring differential susceptibility to Parkinson’s disease, using two genetically distinct…Parkinson’s disease-associated mutations of PLA2G6 alters the membrane dynamics and α-synuclein stability
Objective: To investigate the mechanism of α-synuclein (α-Syn) aggregation. Background: PLA2G6 has been isolated as the gene responsible for an autosomal recessive form of Parkinson’s…Apigenin loaded Phospholipid based nanoemulsion in Therapeutics of Parkinson’s Disease Via Attenuation of Oxidative Stress and Upregulation of Dopamine.
Objective: The aim of the present study was to develop, optimizes and evaluate the antiparkinson effects of apigenin loaded phospholipid based nanoemulsion via attenuation of…
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