MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Dopaminergic neurons"

  • 2023 International Congress

    PASADENA 1-year open-label extension

    G. Pagano, A. Reyes, A. Monnet, M. Martinec, N. Shariati, T. Simuni, K. Marek, R. Postuma, N. Pavese, F. Stocchi, K. Taylor, H. Svoboda, P. Fontoura, G. Kerchner, R. Doody, A. Bonni, T. Nikolcheva (Basel, Switzerland)

    Objective: To describe the results of PASADENA 1-year open-label extension (OLE). Background: Prasinezumab is a humanized monoclonal antibody that binds aggregated alpha-synuclein with the potential…
  • 2023 International Congress

    A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson’s Disease (PADOVA): Rationale, Design, and Baseline Data

    T. Nikolcheva, G. Pagano, N. Pross, T. Simuni, K. Marek, R. Postuma, N. Pavese, F. Stocchi, K. Seppi, A. Monnet, N. Shariati, L. Rutten-Jacobs, S. Zanigni, T. Kustermann, K. Taylor, D. Trundell, H. Svoboda, A. Bonni, P. Fontoura, R. Doody (BASEL, Switzerland)

    Objective: The study will evaluate the efficacy and safety of prasinezumab in individuals with early-stage Parkinson's disease (PD) on stable symptomatic therapy. Background: Available treatments…
  • 2023 International Congress

    Glycated alpha-synuclein and it emerging role in early onset of Parkinson’s disease

    S. Chatterjee, H. Thakkar, A. Khairnar, R. Shah (Gandhinagar, India)

    Objective: To elucidate, the molecular mechanism underlying glycated α-Syn mediated dopaminergic (DAergic) neurodegeneration in the substantia nigra (SN) via the AGE/RAGE signaling pathway. Background: Intracytoplasmic…
  • 2023 International Congress

    Impairment of SHH signaling in PD LRRK2 I1371V iPSC derived floor plate cells contribute to ontogenic origin of lower dopaminergic-neuron yield

    I. Datta, S. Jagtap, C. Potdar, K. Singh (Bengaluru, India)

    Objective: To estimate SHH responsiveness & signaling of Floor Plate Cells (FPCs) derived from LRRK2 I1371V PD patient-iPSCs along with its link with LRRK2 I1371V…
  • 2023 International Congress

    Artificial Intelligence to detect and classify tremors in patients with Parkinson’s disease and related conditions

    T. Elshourbagy, M. Hernandez, G. Mckay, J. Brasic (Cairo, Egypt)

    Objective: To develop a machine learning program to detect and classify tremors in patients with Parkinson's disease (PD) and related conditions. Background: PD is the…
  • 2023 International Congress

    SARS-CoV-2 infection exacerbates the cellular pathology in Parkinson’s disease progression

    HN. Choi, BN. Lee, YH. Che, MG. Ko, HM. Seong, MG. Jo, KS. Lyoo, YJ. Kim, SP. Yun (Jin-Ju, Republic of Korea)

    Objective: This study can provide an important insight for identification and prediction of long term neurological sequelae of SARS-CoV-2 infection and proper clinical management the…
  • 2023 International Congress

    Dopaminergic Neuronal attributes in aging Substantia Nigra and Ventral Tegmental Area of mice strains distinctly sensitive to MPTP

    S. Choudhury, P L. Abhilash, P. Alladi (Bengaluru, India)

    Objective: To determine the age-related changes in neuronal morphology in the substantia nigra pars compacta (SNpc) and Ventral Tegmental Area (VTA) of C57BL/6J and CD-1…
  • 2022 International Congress

    Identification and functional characterization of genetic modifier of penetrance in G2019S LRRK2-associated Parkinson’s disease through family whole genome sequencing

    J. Ohnmacht, D. Bobbili, P. May, E. Glaab, J. Kaye, S. Finkbeiner, R. Krüger (Strassen, Luxembourg)

    Objective: Trait- or disease-associated genetic variants contribute to substantial variability and penetrance of complex traits and diseases in humans. Several causative genes and risk factors…
  • 2022 International Congress

    miR-218-5p Regulates Microglia-mediated Neuroinflammation through Type I Interferon Response in Parkinson’s Disease

    D. Wang, Q. Qin, J. Li, J. Zhao, Z. Mao, Z. Xue (Wuhan, China)

    Objective: To explore the effect of miR-218-5p on microglia activation and dopaminergic neurons damage in mice model of Parkinson's disease(PD) and its potential mechanisms. Background:…
  • 2022 International Congress

    DUtch PARkinson Cohort (DUPARC): Contrast Sensitivity and Retinal Changes in Early Parkinson’s Disease Patients

    C. Gillen, S. Zee, N. Jansonius, T. van Laar (Groningen, Netherlands)

    Objective: To identify and characterize the correlation between static contrast sensitivity (SCS), dynamic contrast sensitivity (DCS), and thickness of the internal plexiform layer (IPL) in…
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