Presynaptic dopamine depletion predicts late complications and time of progression to advanced disease in patients with early Parkinson’s disease
Objective: To investigate whether the degree of reduced dopamine transporter binding in the striatum is a risk factor for late complications and time of progression…The relationship among clinical features, DAT scintigraphy and MIBG cardiac scintigraphy in patients with Parkinson’s disease
Objective: The aim of this study is to evaluate correlations among clinical features of Parkinson's disease (PD), odor stick identification test for Japanese (OSIT-J) score,…Neuromelanin imaging is useful for monitoring disease progression in Parkinson’s disease and PARK2
Objective: Using neuromelanin (NM)-MRI, we analyzed whether disease severity and MF is associated with the degree of dopaminergic neuronal degeneration in the substantial nigra compacta…Study of striatal dopamine transporter function in Alzheimer’s disease with parkinsonism
Objective: To clarify the pathological basis for Alzheimer's disease (AD) with parkinsonism using striatal dopamine transporter (DAT) scan. Background: Pathological basis for parkinsonism in AD…Cellular senescence induced by paraquat drives neuropathology associated with Parkinson’s disease
Objective: To understand the role of cellular senescence in brain aging and neurodegeneration in Parkinson's disease models. Background: Although cellular senescence has been causally linked…Curcumin supplementation improves motor dysfunction in lipopolysaccharide induced Parkinon’s disease model: Possible biochemical, neurochemical and immunohistochemical alterations in rats
Objective: In the present study potential neuroprotective effects of curcumin were tested to determine if they could help to minimize microglia–mediated damage in single intranigral…Generation of dopaminergic neurons for studying Parkinson’s disease using patient blood cells
Objective: To study the molecular mechanism of G2385R mutation of LRRK2 gene in PD developing, dopaminergic neurons are derived from patient specific induced pluripotent stem…Amelioration of αLPHA-synuclein aggregation and motor behavior deficits by apocyanin in intranigral lipopolysaccharide induced animal model of Parkinson’s disease
Objective: The present study evaluated the therapeutic potentials of apocyanin for the treatment of neurobehavioral consequences in LPS induced PD model. Background: Parkinson's disease (PD),…Modulating neuronal activity in dopaminergic neurons to promote their survival
Objective: To manipulate the activity of dopaminergic (DA) neurons in culture using pharmacological and molecular tools to promote their survival. Background: Parkinson's disease is a…A computational model of iron transport between the blood circulation and the brain
Objective: To create a mechanistic computational model of iron transport between the circulation and brain, permitting in silico investigation of homeostatic regulation of iron at…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.