Motor dysfunctions in rats following repeated exposure to stress on the neurotoxicity of lambda-cyhalothrin
Objective: To investigate the targets associated in regulating motor functions following subsequent exposure to stress on the neurotoxicity of lambda-cyhalothrin in rats. Background: Stress that…Non-motor symptoms in Parkinson’s disease and putamen dopamine transporter uptake (DaTscan) uptake: a survey of 85 patients
Objective: We addressed association between 30 non-motor symptoms (NMS) (using the validated Parkinson’s disease (PD) NMS Scale (NMSS)), and DaTscan putamen uptake ratios as part…High-mobility group box 1 from astrocytes upregulates TH expression to maintain dopaminergic neurons via JNK pathway in human Parkinson’s disease patients and MPTP induced mouse model
Objective: Supporting by glial cells could be reinforced the function of dopaminergic neurons against extracellular insults in Parkinson’s disease (PD) development. However, we do not…The Putamen to Caudate Nucleus Ratio: A Simple Surrogate Marker for Dopaminergic Volume in Putamen
Objective: To investigate the simple parameter by which fully represent the level of nigral dopamine in putamen by means of routine 18F-FP-CIT positron emission tomography…Citrus extract A protects dopaminergic neuron by modulating mitochondrial respiration and reactive oxygen species
Objective: This study aims to validate the protective effect of citrus extract A (CEA) against loss of dopamine neurons in PD by dual targeting of…Hypertension and Parkinson’s disease
Objective: To compared clinical burden, neuropsychological features, CSF and imaging pathology in early untreated PD patients with and without HT. Background: Hypertension (HT) has been…CR6-interacting factor1 Deficiency in Dopamine Neurons Triggers Early-onset Parkinsonism in Mice
Objective: One candidate is CR6-interacting factor1 (CRIF1), which controls translation and membrane insertion of 13 mitochondrial proteins involved in oxidative phosphorylation. Here we determined the…Inhibition of mitochondrial complex I synthesis by chloramphenicol mitigates dopaminergic neuronal cell loss in PQ-induced parkinsonism
Objective: To find the potent drug for prevention of PD, we screened with above 1000 drugs in the PQ treated cells which currently used drug…Neural correlates of movement sequence kinematics in substantia nigra dopaminergic cells
Objective: To develop a new behavioral task for assessment of mice forelimb movements, and evaluate the substantia nigra pars compacta dopaminergic cells’ (SNpc) correlates of…Admixing augments nigral dopaminergic correlates during development to impart resistance to MPTP-toxicity at adulthood
Objective: Establish the developmental basis for varying nigral dopaminergic (DA) correlates in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptible C57BL/6, MPTP resistant CD-1 and their resistant crossbred mice. Background:…
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