The neuroprotective properties of NLX-112 in MPTP treated mice are mediated by reactive gliosis and astrocytic GDNF
Objective: To investigate whether NLX-112, a potent and selective 5-HT1A agonist is neuroprotective in a mouse MPTP model of Parkinson’s Disease (PD) [1]. Background: There…Levodopa Carbidopa Intestinal Gel for Parkinson’s Disease over 11 years: A Single Center “Real-World” Experience
Objective: To review long-term real-world experience and clinical outcomes in PD patients with LCIG therapy over 11 years in a multidisciplinary University clinic setting. Background:…Ventral tegmental deep brain stimulation does not influence risk-taking behaviour in a standard gambling task
Objective: We here used a standard gambling task that involved risky decision-making. This permitted us to measure the effects of ventral tegmental area (VTA) deep…Parkin Coregulates Glutathione Metabolism in Adult Brain to Contribute to Redox Homeostasis
Objective: We sought to determine whether the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis in vivo. Background: The mechanisms by which…Dopamine depletion of striatal subregions and motor dysfunction in prodromal and clinical Parkinson’s disease
Objective: This aim of this study was to investigate how dopamine depletion of different striatal subregions contributes to motor symptoms in patients with prodromal and…Diagnostic challenges in a case of SLC6A3-related Dopamine Transporter Deficiency Syndrome
Objective: We report a case presenting with symptoms of classical Dopamine Transporter Deficiency Syndrome (DTDS) with negative results on initial whole-exome sequencing (WES), but eventually…Insular dopamine deficits in prodromal α-synucleinopathies
Objective: aim of the study was to evaluate the dopamine binding characterizing subjects both at prodromal and symptomatic stages in α-synucleinopathies, by means of ROI-based…Education and the motor effects of dopamine loss in Parkinson’s disease
Objective: To examine the relation between education and dopamine signal loss in PD. Background: In support of the cognitive reserve concept, it has consistently been…Diabetes impact on nigrostriatal vulnerability in Parkinson’s Disease
Objective: aim of the study was to investigate whether diabetes mellitus influences nigrostriatal dopaminergic vulnerability in drug-naïve patients with early-stage Parkinson’s Disease (PD). Background: recently,…Differential effect of dopaminergic medication on smooth pursuit vs. saccadic eye movements Parkinson’s disease
Objective: To assess the effect of dopaminergic medication on eye movements in Parkinson’s disease (PD). Background: PD is the second most common neurodegenerative disease, characterised…
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