Comparison of DAT scan, cardiac MIBG scintigraphy, and cerebrospinal fluid 5HIAA levels in Parkinsonian syndrome
Objective: To assess the associations of presynaptic dopamine transporter (DAT scan), cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy, and cerebrospinal fluid (CSF) levels of 5-hydroxyindole acetic acid (5HIAA)…AMP kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons
Objective: To characterize the effect of AMP-activated protein kinase (AMPK) on ATP-sensitive K+ (K-ATP) channels on substantia nigra compacta (SNC) dopamine neurons in slices of…Evaluation of regional changes in striatal DAT binding in a progressing Parkinson’s disease (PD) cohort: Lessons for imaging biomarker assessment in disease-modifying therapeutic trials
Objective: To evaluate subregion-dependent striatal changes in dopamine transporter (DAT) binding using 123-I Ioflupane SPECT in PD participants in the Parkinson Progression Marker Initiative (PPMI)…The efficacy of quantitative 99mTc-TRODAT-1 SPECT in diagnosis of aged patients with Parkinson’s disease
Objective: We aim to establish the normal reference with quantitative 99mTc-Trodat-1 (TRODAT) SPECT and verify the diagnostic performance in aged Parkinson's disease (PD) patients. Background:…Neuroprotection effect of an endogenous amine, 1MeTIQ against disturbances in dopamine release induced by the neurotoxin, 6-OHDA: In vivo microdialysis study
Objective: The aim of the present study was to investigated using microdialysis methodology the impact of 1MeTIQ on the disturbances of in vivo dopamine release…Carrier mediated delivery system bearing dopamine for effective management of parkinsonism
Objective: In the present investigation, amino acid coupled liposome bearing dopamine-HCl were prepared to deliver drug to the brain utilizing receptor-mediated transcytosis for effective management…Vagus nerve stimulation as a novel treatment strategy for Parkinson’s disease
Objective: To assess the therapeutic potential of chronic vagus nerve stimulation (VNS) to attenuate the behavioral and neuronal deficits observed in Parkinson's disease (PD) by…Dopaminergic medication affects choice bias in Parkinson’s disease
Objective: Assess dopaminergic effects on choice bias in Parkinson's disease (PD). Background: Bradykinesia, rigidity and resting tremor are the core symptoms of PD, but many…Neuroprotective and antidepressant-like effects of the endogenous amines from tetrahydroisoquinoline group TIQ and 1MeTIQ in the animal model of depressive disorder: Behavioral and neurochemical studies in the rat
Objective: For the purpose of estimation neuroprotective and antidepressant-like effects of the endogenous amines 1,2,3,4-tetrahydroisoquinoline (TIQ) and its close methyl derivative, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) in the…Tau dysfunction in the basal ganglia of a mouse model of tauopathy related to PSP
Objective: Determine motor coordination and neurochemical phenotypes in the basal ganglia of mice lacking the Tau protein or expressing an abnormal content of Tau isoforms.…
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