Functional MAOB gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson’s disease
Objective: To examine the effects of common functional polymorphisms in genes involved in dopamine metabolism on striatal dopamine turnover estimated as the inverse of the…Development of nano-formulation containing crocetin for the protective and beneficial effect against 6-hydroxydopamine induced Parkinson’s disease model via altered the genetic backgrounds
Objective: Parkinson’s disease (PD) induced by the interaction between the number of factors viz., aging, genetics toxins, mitochondrial deformity and oxidative stress. Various evidences suggest…Exercise alters response of reward anticipation in the ventral striatum of subjects with Parkinson’s disease
Objective: To investigate the effects of exercise on reward circuitry in Parkinson’s disease (PD). Background: The benefits of exercise in PD have been linked to…Reduced lifespan and climbing ability observed in the overexpressing human α-synuclein without heat shock protein CNB115 in Parkinson’s disease drosophila line
Objective: To investigate the neurotoxic role of overexpressing α-synuclein without Heat Shock Protein CNB115 (HSP115) in Parkinson's disease Drosophila line. Background: Parkinson's disease (PD) is…Prevalence of impulse control disorders among adult Filipino patients with idiopathic Parkinson’s disease seen at a tertiary center in Manila
Objective: (1) To determine the prevalence and severity of Impulse Control Disorders (ICDs) in adult Filipino patients with idiopathic Parkinson's disease seen at a tertiary…Consolidation of learning and memory in Parkinson’s disease
Objective: To determine if Parkinson's disease causes an impairment in the ability to consolidate learning into long-term memory and to determine if this deficit is…Subthalamic nucleus deep brain stimulation modulate catecholamine levels with significant relations to clinical outcome after surgery in patients with Parkinson’s disease
Objective: Because subthalamic nucleus deep brain stimulation is effective in L-3,4-dihydroxyphenylalanine responsive patients with Parkinson's disease (PD), the preoperative catecholamine levels may affect the effect…Functional characterisation and the selective vulnerability of SNCA (A30P) patient-derived midbrain dopaminergic neurons to ER stress
Objective: To functional characterise and phenotype the genetic Parkinson's disease (PD) patient with an A30P point mutation in SNCA using midbrain dopaminergic neurons (mDANs) vs…Dopamine reduces Parkinson’s tremor through increased thalamic inhibition
Objective: To identify cerebral mechanisms explaining the effects of dopamine on rest tremor in Parkinson's disease. Background: Resting tremor in Parkinson's disease is related to…Anxiety and cognition are associated with dopaminergic dysfunction in de novo Parkinson’s disease
Objective: To explore the relationships between nigrostriatal dysfunction and both neuropsychiatric (including anxiety, depression and apathy) and cognitive symptoms in newly diagnosed, drug-naive Parkinson's disease…
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