Localization and functional study of synaptic vesicle protein synaptogyrin-3 (SYNGR3) on dopaminergic neuronal system
Objective: To investigate (1) the intracellular localization of SYNGR3 and its interaction with dopamine transporter (DAT); (2) how expression of SYNGR3 in neurons affects dopamine…Visual vs. automated analysis of [123I]FP-CIT SPECT scans in patients with parkinsonism
Objective: To investigate the differences between visual and automated analyses of brain dopamine transporter (DAT) SPECT scans. Background: Clinical evaluation of DAT SPECT scans typically…Improving clinical detection of balance deficits in individuals with Parkinson’s disease with and without freezing of gait and the effects of dopaminergic replacement therapy
Objective: Since it has been argued that PD+FOG have greater sensory impairments compared to PD-FOG, the current study evaluated whether the modified Clinical Test of…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…The role of striatal dopaminergic terminals in early de novo PD patients with speech impairment
Objective: To assess the role of striatal dopaminergic terminals in early de novo (untreated) Parkinson's disease (PD) patients with impairment of speech. Background: Dopamine has…Effect of dopamine and L-3,4 – dihydroxyphenylalanine in treatment of experimental parkinsonism
Objective: To study effect of dopamine and L-3,4 - dihydroxyphenylalanine in treatment of experimental parkinsonism. Background: Prospects of treatment of Parkinson's disease are also closely…Differential expression of cerebral dopamine neurotrophic factor (CDNF) in the hippocampus and in the striatum of LRRK-2 mutant rat model of Parkinson’s disease
Objective: The objective of our study was to characterize the behavioral phenotype of the transgenic LRRK-2 rat in the context of PD model and to…Increasing placebo response in Parkinson’s disease through apomorphine pre-conditioning
Objective: To see whether a placebo response requires pharmacological pre-conditioning with apomorphine. Background: Placebos have been found to affect the patient's brain in a number…The neurosteroid dehydroepiandrosterone sulfate (DHEAS) reverses the dopaminergic deficiencies in mild hepatic encephalopathy: A possible therapeutic issue for the management of parkinsonism in cirrhotic patients
Objective: In the present study, we describe the changes of the dopaminergic system occurring in the cirrhotic rats and concomitantly we investigated the effect of…Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation
Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…
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