Dopamine Normalizes Putamen to Insula Activation Shift During Choice Reaction Time Task in PD
Objective: We investigated Parkinson’s disease (PD) patients during a functional MRI Choice Reaction Time (CRT) task and determined whether brain activations are altered by dopamine. Background:…Alpha-synucleinopathy and mitochondrial dysfunction in a cell based model of neurodegeneration: Implications in the pathogenesis of sporadic Parkinson’s disease
Objective: To elucidate the role of α-synuclein, parkin and mitochondria in a cell-based model of neurodegeneration relevant to Parkinson's disease pathogenesis. Background: The suggested mechanisms…Functional MAOB gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson’s disease
Objective: To examine the effects of common functional polymorphisms in genes involved in dopamine metabolism on striatal dopamine turnover estimated as the inverse of the…Development of nano-formulation containing crocetin for the protective and beneficial effect against 6-hydroxydopamine induced Parkinson’s disease model via altered the genetic backgrounds
Objective: Parkinson’s disease (PD) induced by the interaction between the number of factors viz., aging, genetics toxins, mitochondrial deformity and oxidative stress. Various evidences suggest…Exercise alters response of reward anticipation in the ventral striatum of subjects with Parkinson’s disease
Objective: To investigate the effects of exercise on reward circuitry in Parkinson’s disease (PD). Background: The benefits of exercise in PD have been linked to…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Neuroactive steroids reverse the dopaminergic neurotransmission defectiveness in chronic hepatic (HE) encephalopathy: a possible involvement in HE related parkinsonism
Objective: In the present study, we describe the changes of the dopaminergic system occurring in the cirrhotic rats and concomitantly we investigated the effect of…Personal KinetiGraph Devices Assessing Efficacy of Continuous Enteral Carbidopa/Levodopa Infusion Therapy
Objective: To assess the utility of Personal KinetiGraph (PKG) devices to objectively quantify difference in motor symptoms and motor fluctuations before and after the initiation…Lifetime exposure to estrogen and risk for progressive supranuclear palsy
Objective: To investigate the protective effect of estrogen on progressive supranuclear palsy (PSP). Background: Animal and human epidemiologic studies of Parkinson’s disease and Alzheimer’s dementia have…Intracerebroventricular administration of dopamine: A new therapeutic concept for Parkinson’s disease?
Objective: In this study, we aim to demonstrate that continuous i.c.v. infusion of dopamine close to the striatum is a feasible and highly efficient treatment…
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