Carrier Mediated Delivery System Bearing Dopamine for Effective Management of Parkinsonism
Objective: In the present investigation, amino acid coupled liposomes bearing dopamine-HCl were prepared to deliver drug to the brain utilizing receptor-mediated transcytosis for effective management…The contribution of striatal dopamine to feedforward motor control during gait initiation in Parkinson’s disease
Objective: To establish the contribution of striatal dopamine to gait initiation in Parkinson’s disease. Background: Gait initiation (GI) is characterized by anticipatory postural adjustments (APAs),…Memory enhancing effect of Combined Alcoholic Extract of Cedrus deodara Loud. and Vitex Nirgundi in scopolamine-induced cognitive impairment in mice
Objective: Epidemiological studies of Indian population reveal that dementia is largely a hidden problem in India. Ayurveda claims several plants are beneficial in cognitive disorders.…Tissue Engineered Nigrostriatal Pathway as an Anatomically-Inspired Test-Bed for Evaluating Axonal Pathophysiology
Objective: We previously developed the first micro-tissue engineered nigrostriatal pathway encased in a tubular hydrogel with 3D structure, multicellular composition, and architecture of long axonal…Dielectric Properties of a Blood Plasma Predict Motor Deficits in a 6-Hydroxydopamine-Induced Rat Model of Parkinson’s Disease
Objective: This study presents a novel method of predicting the behavioral pattern in male Sprague-Dawley rats with motor deficits impairment, based on the measurement of…Glabellar tap predicts dopamine transporter deficiency in parkinsonism
Objective: The objective of this study was to investigate the association between glabellar tap findings with nigrostriatal dopamine function in patients with unclear parkinsonism. Background:…Comparison between [11C]PE2I PET and [123I]FP-CIT SPECT as markers of DAT expression in early Parkinson’s disease
Objective: To compare single-photon emission computed tomography (SPECT) with [123I]FP-CIT and positron emission tomography (PET) with [11C]PE2I as markers of dopamine transporter (DAT) loss in…Neuroprotective role of Tinospora cordifolia in MPTP induced Parkinsonian mouse model
Objective: To evaluate the neuroprotective effect of Tinospora cordifolia aqueous extract (TCAE) in Parkinsonian mice. Background: Parkinson’s disease, an age related neurodegenerative disorder, is characterized…EEG microstates changes in response to increase in dopaminergic stimulation in treated typical Parkinson’s disease patients without clinical fluctuations
Objective: Neurotropic drugs may modulate Electroencephalography (EEG) microstates (MS), but there are no works showing EEG MS default-mode network changes in response to dopaminergic stimulation…Catecholamines interrelation in plasma of early diagnosed treatment-naive patients with Parkinson disease
Objective: To investigate the interrelation of catecholamines in the blood plasma of healthy people and PD patients. Background: The study “START-1” was funded by Investment…
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