Blockade D1-like and D2-like dopamine receptors within nucleus accumbens attenuate hyperalgesia responses in a 6-OHDA induced parkinson’s disease rat model
Objective: To investigate the role of blockade D1-like and D2-like dopamine receptors within nucleus accumbens attenuate hyperalgesia responses in a 6-OHDA induced parkinson’s disease rat…STN DBS – A study of frequency of gait (fog) in Parkinson’s disease
Objective: In search of new techniques to help improve lifestyle of Parkinson`s diseased conditions (PDs), a wireless technique is proposed to identify freeze, reduce freeze,…Patterns of Striatal DAT Binding Loss in a Progressing Parkinson Disease (PD) Cohort: Four year PPMI Follow-up
Objective: To evaluate within subject striatal changes in dopamine transporter (DAT) binding using 123-I Ioflupane SPECT in PD participants studied over four years in the…Self-rated burden grading of nonmotor symptoms identifies landmarks and subtypes of Parkinson’s disease: first report from a Moscow-Madrid-London collaboration
Objective: To describe clinical and imaging biomarkers of nonmotor symptoms burden (NMSB) as defined by NMS questionnaire (NMSQ) scores in a prospective international cohort study…D2 receptor mediated DARPP32/PP1α signaling is responsible for cadmium induced Parkinson’s like behavioral alterations in rats
Objective: To identify the specificity of dopamine D2 receptor mediated signaling in cadmium mediated motor alterations Background: Cadmium, a heavy metal, is to known to…DaTscan in clinical evaluation of Multiple System Atrophy
Objective: To explore accuracy of DaTscanTM Ioflupane I123 Injection (DaTscan) in a multiple system atrophy (MSA) cohort Background: There are isolated cases of normal DaTscan in neuropathologically confirmed MSA-cerebellar subtype (MSA-C)…99mTc-TRODAT-1 SPECT imaging in early and late onset Parkinson’s disease.
Objective: In this study we tried to determine the TRODAT SPECT findings in EOPD as compared to LOPD. Background: 99mTc-TRODAT-1, which binds to the dopamine…Clinical Utility of Optimized Parameters for a Quantitative Analysis of 123I-ioflupane SPECT (DaTscan) Images
Objective: Validate an automated analysis of DaTscan SPECT images on a representative cohort of patients for discriminating between Parkinson's Disease (PD) versus non-PD. Background: Quantitation…Global Regulatory Agencies Support the Use of Dopamine Transporter Neuroimaging for Subject Selection in Clinical Trials Targeting Early Stage Parkinson’s Disease – on behalf of Critical Path for Parkinson’s (CPP) Consortium
Objective: A key goal of the Critical Path for Parkinson’s Consortium (CPP) is to qualify, with regulatory agencies, drug development tools for use in PD…Chronic levodopa treatment accelerates the disorders of circadian rhythm in 6-OHDA induced Parkinson’s disease model
Objective: We aimed to study the effect of levodopa on circadian rhythms in 6-OHDA lesioned rats, and to clarify whether the disturbance of the circadian…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.