Noradrenaline treatment of apathy and impulsivity in participants with Progressive Supranuclear Palsy syndromes (NORAPS). A Phase II clinical trial – ISRCTN99462035.
Objective: The NORAPS Phase II clinical trial seeks to demonstrate safety, tolerability and efficacy of atomoxetine in Progressive Supranuclear Palsy (PSP). Background: PSP is a…EFFECTS OF DOPAMINERGIC MEDICATION ON REACTIVE AND PROACTIVE INHIBITORY CONTROL
Objective: In this study, we aim to address the effects of dopaminergic treatment (DT) on the two domains of motor inhibition [1], i.e., reactive (the…Dopamine-independent cortical disinhibition in Parkinson’s disease
Objective: To test the hypothesis that cortical disinhibition in Parkinson's disease is a dopamine-independent process. Background: Motor cortex alterations in Parkinson's disease are classically considered…High- and Low-Frequency Deep Brain Stimulation in the Subthalamic Nucleus differentially modulate Response Inhibition and Action Selection in Parkinson’s Disease
Objective: The aim of this project was to investigate how high- and low-frequency deep brain stimulation (DBS) modulate impulsive actions in the antisaccade task as…Effect of oxytocin on response inhibition in Parkinson´s disease: a pilot study
Objective: To observe the effect of oxytocin (OXT) on response inhibition in Parkinson´s disease (PD) patients using dedicated saccadic tasks. Background: Cumulating evidence has shown…The volume of STN tissue activated by DBS and the strength of its structural connectivity with SMA predicts the effects of STN-DBS on response inhibition
Objective: To test the hypothesis that antidromic activation of the hyperdirect pathway might mediate the effects of STN-DBS on movement initiation control. Background: In PD,…Decreased mesencephalic locomotor region activation explains loss of presynaptic inhibition during step initiation in people with Parkinson´s disease with freezing of gait
Objective: To investigate if decreased mesencephalic locomotor activation (MRL) activation during step initiation in an-event related fMRI protocol would explain the loss of presynaptic inhibition…Sensorimotor inhibition relates to gait dysfunction in people with Parkinson’s disease
Objective: To determine how sensorimotor inhibition relates to objective measures of gait OFF and ON levodopa and how having Parkinson’s disease (PD) affects this relationship.…Impaired inhibitory control of saccadic eye movements in cervical dystonia: an eye tracking study
Objective: The aim of the present study was to assess the oculomotor performance of CD patients using eye tracking saccade paradigms. Background: The pathophysiology of…Loss of cortical inhibition in Parkinson’s disease
Objective: To evaluate motor cortex inhibition at different stages of Parkinson’s disease (PD). Background: In PD, striatal dopamine depletion produces profound alterations in the neural…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.