Neuroprotective Role of Diosgenin-Loaded Lipid Nanoparticles for Parkinson’s Disease: Pharmacokinetic and Pharmacodynamic Insights
Objective: To develop, optimize, and evaluate diosgenin-loaded solid lipid nanoparticles (DG-SLNs) and nanostructured lipid carriers (DG-NLCs) incorporated into hydrogel formulations (DG-SLN-C and DG-NLC-C) for improved…Peripheral insulin resistance may predict exenatide treatment response in Parkinson’s disease
Objective: To explore if the glucagon-like peptide-1 (GLP-1) receptor agonist, exenatide could modify the course of Parkinson’s disease (PD) and if peripheral insulin resistance (IR) mightdifferentially impact on this. Background: Exenatide…Therapeutic Efficacy of Human Dental Pulp Stem Cells-Derived Exosome-Encased Phloroglucinol In MPTP-Induced Chronic Parkinsonian Rat model: Potential for Disease Modification
Objective: This study aimed to evaluate the therapeutic efficacy of intranasally administered exosome-encased phloroglucinol (Exo-Phl) in a MPTP rat model of PD. Background: Dopaminergic (DA)…Cognitive and Motor Wobbling in Isolated RBD: A Multicentric Study by the International RBD Study Group (IRBDSG)
Objective: To define and characterize clinically fluctuating transition phases from isolated RBD (iRBD) to overt alpha-synucleinopathy. Background: Patients with iRBD often develop motor and non-motor…Beyond Medication: The Potential of Diet in Parkinson’s Management
Objective: To assess the effects of diet and dietary supplements on motor/non-motor symptoms, and disease progression in Parkinson disease (PD). Background: Diet has generally played…A multi-center, randomized, controlled study of the add-on effect of selegiline or zonisamide to L-dopa/DCI therapy in Parkinson’s disease (DATSZ-PD study)
Objective: To investigate the efficacy and safety for neuroprotection and disease modifying effect in selegiline(SL) or zonisamide(ZN) by using UPDRS, PDQ-39 and DAT -SPECT in…A Novel Therapeutic Targeting the tPA-NMDAr Interaction for Parkinson’s Disease
Objective: Glunomab, a monoclonal antibody designed to inhibit the interaction between tissue plasminogen activator (tPA) and the N-methyl-D-aspartate receptor (NMDAr), has demonstrated therapeutic potential across…Prodromal Parkinson’s Disease in Agent Orange Exposed US Vietnam Veterans
Objective: 1-Comparing the risk of prodromal PD between AO exposed veterans (AOEV) and non-AO exposed veterans without PD (Controls) in a Veterans Affairs (VA) hospital…VGN-R09b, an Adeno-associated virus-based Combination Gene Replacement Therapy for Parkinson’s Disease
Objective: Develop a sustained disease modifying gene therapy for treating Parkinson’s disease Background: Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons…Educational Strategies for Enhancing Caregiver Knowledge and Capacities in Parkinson’s Disease Management: A Comprehensive Review
Objective: To evaluate the effectiveness of educational strategies in enhancing caregiver knowledge, skills, and confidence in managing Parkinson’s disease (PD) and to identify gaps in…
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