The effect of istradefylline on mood disorders in Parkinson’s disease
Objective: The effectiveness of istradefylline for treatment of mood disorders in patients with Parkinson's disease (PD) was examined in an open-label trial. Background: Depression is…Open-Label Study of Pimavanserin Patients With Comorbid Parkinson’s Disease and Depression
Objective: We are assessing use of pimavanserin (PIM) for treatment of depression in adults with PD. Background: Depression occurs in ~50% of Parkinson’s disease (PD)…The effects of zonisamide on motor and non-motor symptoms in patients with Parkinson’s disease: a 3-month open-label study
Objective: To investigate the effect of zonisamide (ZNS) on motor and non-motor symptoms, such as depressive symptoms and sleep problems, in patients with Parkinson’s disease…Higher levels of physical activity is associated with fewer non-motor symptoms in early Parkinson’s disease: a 1-year follow-up study
Objective: To examine the physical activity (PA) level in early Parkinson’s disease (PD) patients and its association with non-motor symptoms (NMS). Background: Lower PA is…Vortioxetine treatment of depression in Parkinson’s disease
Objective: To assess efficacy and safety of Vortioxetine in Parkinson’s Disease (PD) patients affected by depression and its effects on motor performance. Background: Depression is…Impact of a high-fat diet on the behavior of A53T alpha-Synuclein Parkinson’s disease mice
Objective: The aim of this project was to evaluate high-fat diet (HFD) induced behavioral alterations in the A53T alpha-Synuclein Parkinsons’s disease mouse model. Background: Besides…Influence of Cognitive Deficits and Tremor Severity of the Development of Depression in Nondemented Patients with Essential Tremor
Objective: The aim of this study was to investigate the relationship between cognitive deficits and tremor severity with the development of depression in nondemented ET…Neuropsychiatric manifestations in Parkinson’s disease
Objective: Evaluate the different neuropsychiatric manifestations in Parkinson's disease. Background: Parkinson's disease (PD) is the second most common neurodegenerative pathology after Alzheimer's disease, although PD…Pramipexole regulates the depressive-like symptom through dopamine D3 not dopamine D2 receptor in a mouse model of Parkinson’s disease
Objective: The aim of this study is to understand if the antidepressant effect of pramipexole is mediated by D2R or D3R in a mouse model…Pursuit of Psychosocial Intervention for Depression and Anxiety in Japanese Parkinson’s Disease patients: Two Studies of Cognitive Behavioral Therapy
Objective: From 2013 to the present, we have explored the feasibility of cognitive behavioral therapy (CBT) for Japanese Parkinson’s disease (PD) patients with depression and…
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