SNCA multiplication consortium: Clinicogenetic analysis of SNCA multiplication probands and families.
Objective: Clinicogenetic analysis of 57 affected probands with SNCA multiplication, 3 unaffected carriers, and their 60 families. To use informative pedigrees to identify penetrance modifiers…Validation of the performance based Erlangen Test of Activities of Daily Living in PD
Objective: The Erlangen Test of Activities of Daily Living (E-ADL) is a performance-based test to assess the activity of daily living (ADL) dysfunction associated with…Patient-reported hallucinations and the probability of progression to dementia in Parkinson’s disease
Objective: To evaluate the influence of neuropsychiatric symptoms in identifying Parkinson’s disease (PD) patients who will progress to dementia (PDD) in the imminent future (~4…Association of the GBA T369M polymorphism with motor and cognitive symptoms in Parkinson’s disease
Objective: To determine whether the GBA polymorphism T369M is associated with earlier age of onset, lower cognitive performance, and more severe motor impairment in Parkinson's…Use of pimavanserin in patients with Parkinson’s disease psychosis: Subgroup analysis of efficacy and safety in patients with and without cognitive impairment
Objective: A planned subgroup analysis of a phase 3 study was performed to evaluate the efficacy and safety of pimavanserin (PIM) in Parkinson’s disease psychosis…Self-awareness of cognitive functions in Parkinson’s disease patients with and without mild cognitive impairment.
Objective: To examine whether Parkinson’s disease (PD) patients with or without mild cognitive impairment (MCI) show impaired self-awareness (ISA) of their cognitive abilities. Background: PD…Rationale and Design of a Phase 2 Study to Evaluate the Efficacy of Intepirdine (RVT-101) in Improving Gait and Balance in Patients with Dementia
Objective: To describe the rationale and design of a Phase 2 study that evaluates the effect of intepirdine (RVT-101) on gait and balance in patients…Cognitive decline in Parkinson’s disease: Impact on quality of life of caregivers
Objective: This study aimed to investigate the impact of cognitive impairment in Parkinson's disease (PD) on the quality of life (QoL) of carers. Background: The…Does cognitive decline contribute to poorer quality of life in incident Parkinson’s disease? A three year follow up
Objective: To investigate the impact of cognition and cognitive decline on quality of life (QoL) in an incident Parkinson's disease (PD) cohort over three years.…Reliability of verbal and written trail test for individuals with Parkinson’s disease: Is it a good cognitive test?
Objective: To verify if the verbal trail test can replace the written trail test, seeing that individuals with PD show considerable motor abnormalities that can…
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