Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Progressive Dynamic Functional Network Disorganisation and its Association with Phenoconversion in Isolated REM Sleep Behaviour Disorder: A Multicentre Study
Objective: To characterise static and dynamic functional connectivity signatures of disease progression and phenoconversion in a multicentre longitudinal cohort of individuals with isolated REM sleep…Cholinergic Pathway Degeneration Predicts Differential Phenoconversion to Synucleinopathies in Idiopathic REM Sleep Behavior Disorder
Objective: This cross-sectional and longitudinal study aimed to elucidate the pattern of cholinergic white matter pathway degeneration underlying the phenoconversion trajectories in iRBD patients. Background:…Non-Rapid Eye Movement Sleep Neurophysiological Alterations in Lewy Body Disorders
Objective: To characterise NREM sleep neurophysiology across multiple domains in Lewy body disorders (LBDs) relative to healthy controls. Background: Sleep disturbances are highly prevalent in…Remote Longitudinal Follow-up of Participants in the Parkinson’s Progression Markers Initiative (PPMI)
Objective: To assess a personalized protocol focused on maintaining contact for long-term follow-up of current and former clinical research participants Background: PPMI-FOUND enrolls participants at…Prevalence and Clinical Determinants of Cognitive Impairment in a Diverse Parkinson’s Disease Cohort
Objective: To estimate the prevalence of cognitive impairment in a diverse Parkinson’s disease (PD) cohort and explore its associations with vascular, motor, and non-motor determinants.…Patterns and Predictors of Cholinesterase Inhibitor Use in Dementia with Lewy Bodies
Objective: The objective of this study was to identify the patterns and predictors of cholinesterase inhibitor (ChEI) prescribing in Dementia with Lewy bodies (DLB) patients.…Stratification study of alpha-synucleinopathy by body fluid biomarkers
Objective: This study aims to stratify patients with Parkinson's disease (PD) based on clinical features and several disease-associated biomarkers by analyzing the relationship between biomarkers,…Development of the Lewy Body Dementia Domain Rating Scale (LBD-DRS): A disease-specific outcome measure
Objective: To develop and refine the Lewy Body Dementia Domain Rating Scale (LBD-DRS) as a disease-specific outcome measure tailored to the unique clinical features of…Neural Signatures of Hallucination Emergence in Dementia with Lewy Bodies
Objective: REM sleep behavior disorder (RBD) is a prodromal state for alpha-synucleinopathy. Here, we present a behavioral marker for hallucination propensity that distinguishes Dementia with…
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