Understanding Sleep-wake Disturbances in Dementia with Lewy Bodies Using Parametric and Non-parametric Measures in Wrist Actigraphy
Objective: To assess rest-activity and circadian rhythm stability in Dementia with Lewy bodies (DLB) and their relationship with cognitive, behavioural, and quality of life measures.…Microstructural Changes in the Inferior Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disease
Objective: Identify neuroimaging correlates of excessive daytime sleepiness in Lewy body disorders using diffusion MRI. Background: Excessive daytime sleepiness (EDS) is a common and disabling…EEG dominant frequency as a potential biomarker of cognition in Lewy body diseases.
Objective: To determine whether cognitive performance correlates with posterior dominant frequency across Lewy body diseases. Background: DLB and PDD are associated with prominent posterior slow-wave…Visual Hallucinations and Pareidolias Across the Lewy Body Disease Spectrum
Objective: To systemically evaluate visual hallucinations and illusions in patients across the LBD spectrum and to discover the underlying neural mechanism behind these visual symptoms.…Association of β-Amyloid Load on PET with Cognitive Profiles Across the Lewy Body Diseases Continuum
Objective: To investigate the association between Aβ accumulation and clinical characteristics across the Lewy body disease (LBD) spectrum, with a specific focus on global and…Early changes in the locus coeruleus in mild cognitive impairment with Lewy bodies
Objective: To evaluate NMS signal changes in the locus coeruleus (LC) in mild cognitive impairment with Lewy bodies (MCI-LB) as compared to healthy controls (HC)…Prediction of Time-to-Phenoconversion to Parkinsonism in Idiopathic REM Sleep Behavior Disorder (iRBD)
Objective: To develop a tool for the prediction of time-to-phenoconversion in individuals with iRBD during the prodromal stage of parkinsonism. Background: Parkinson’s disease(PD) and dementia…Common Genetic Variation Associated with Parkinson’s Disease Biological Measures
Objective: To identify common genetic variants associated with biological measures that have been implicated in Parkinson’s disease and related synucleinopathies. Background: Alpha synucleinopathies, mainly including…Plasma Biomarkers of Alzheimer’s Pathology Identify Prodromal Dementia with Lewy bodies
Objective: To determine whether plasma biomarkers of Alzheimer’s disease (AD) pathology can predict phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to dementia with Lewy…Association Between DPP-4 Inhibitors Use and Risk of Dementia: A Meta-analysis Using Real-world Data
Objective: To investigate the potential association between the use of DPP-4 inhibitors and the risk of dementia, utilizing real-world data from diverse sources. Background: Evidence…
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