Efficacy and safety of Rasagiline in treatment of gait disturbances in dementia with Lewy bodies
Objective: We aimed to investigate the efficacy and safety of rasagiline in addition to levodopa in patients with dementia with Lewy bodies (DLB). Background: Management…Insulin degrading enzyme, a novel key protein against alpha-synuclein oligomers formation?
Objective: The objective of this work is to study the interaction between α-synuclein and the insulin degrading enzyme in the pancreas of subjects with synucleinopathies.…Polysomnographic data in Dementia with Lewy Bodies: Correlation with clinical features and comparison with other alfa-synucleinopathies
Objective: 1) Polysomnography (PSG) assessment of sleep in Dementia with Lewy Bodies (DLB). 2) Correlation between PSG data, fluctuations and hypersomnolence. 3) Comparison of PSG…Interaction of TDP-43 with IAPP in pancreatic beta cells of patients with sinucleinopathies
Objective: We have investigated whether deposits of phosphorylated TDP-43 might be present in pancreatic tissue of patients with synucleinopathies. Background: The TAR DNA binding protein…Voxel-based Analysis of Cholinesterase Inhibitor Response in Lewy Body Disorders: A Prospective Observational Study
Objective: The objective is to investigate functional neuroimaging correlates of response to ChEIs in LBD. Background: Lewy body disorders (LBD), including dementia with Lewy bodies…Defective visual perception in patients with Lewy body disease: assessment of hallucinations with pareidolia test.
Objective: Hallucination is a common feature in patients with advanced Parkinson’s disease(PD) and dementia with Lewy bodies (DLB). Background: The pareidolia test is a tool…Feasibility, tolerability and acceptance of a psychosocial intervention for people with Parkinsonian dementia: The INVEST trial.
Objective: To compare a companion-guided, home-delivered psychosocial stimulation intervention to treatment as usual (TAU) to inform a large-scale efficacy trial for people with cognitive impairment…A new psychosocial intervention for people with Parkinsonian dementias: Adherence, barriers and facilitators
Objective: To investigate participant adherence and engagement to a home-based, companion-guided cognitive stimulation therapy adapted for people with Parkinsonian dementias (CST-PD). Background: Adherence to rehabilitation…Do Acetylcholinesterase Inhibitors (AChEI) delay institutionalisation in Parkinson’s and Lewy Body Disease?
Objective: We explored the use of Rivastigmine in Parkinson’s and Lewy body dementia through assessment of quantitative data obtained from a clinical database. We focussed…Glucocerebrosidase mutations in neurodegenerative disorders other than Parkinson’s disease
Objective: To determinate the frequencies of lysosomal glucocerebrosidase (GBA) common mutations in a large sample of neurodegenerative diseases including Alzheimer Disease (AD), Lewy Body Dementia (LBD), Amyotrophic…
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