Interaction of TDP-43 with IAPP in pancreatic beta cells of patients with sinucleinopathies
Objective: We have investigated whether deposits of phosphorylated TDP-43 might be present in pancreatic tissue of patients with synucleinopathies. Background: The TAR DNA binding protein…Effect of Viewpoint and Visual Texture on Object Recognition in Dementia with Lewy Bodies and in Alzheimer’s Disease
Objective: To examine the effect of viewpoint and visual texture on visual object recognition in mild cognitive impairment (MCI) or dementia due to DLB or…Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies…Papez circuit atrophy in Dementia with Lewy Bodies
Objective: In this ex-vivo study, we aimed to assess atrophy in regions and subregions of the Papez Circuit, a network important for memory function, in…A new psychosocial intervention for people with Parkinsonian dementias: Adherence, barriers and facilitators
Objective: To investigate participant adherence and engagement to a home-based, companion-guided cognitive stimulation therapy adapted for people with Parkinsonian dementias (CST-PD). Background: Adherence to rehabilitation…Do Acetylcholinesterase Inhibitors (AChEI) delay institutionalisation in Parkinson’s and Lewy Body Disease?
Objective: We explored the use of Rivastigmine in Parkinson’s and Lewy body dementia through assessment of quantitative data obtained from a clinical database. We focussed…Glucocerebrosidase mutations in neurodegenerative disorders other than Parkinson’s disease
Objective: To determinate the frequencies of lysosomal glucocerebrosidase (GBA) common mutations in a large sample of neurodegenerative diseases including Alzheimer Disease (AD), Lewy Body Dementia (LBD), Amyotrophic…Delusional Misidentification Syndrome for “Self” in two patients with Parkinson`s Disease.
Objective: We report two patients with Parkinson’s disease(PD) and Capgras syndrome (CS) with confusion of identify not just of close acquaintances but also of “self”.…A Phase 2 Study of Nelotanserin, a Novel 5HT2A Receptor Inverse Agonist, in Dementia with Lewy Bodies and Parkinson’s Disease Dementia Subjects Experiencing Visual Hallucinations
Objective: To evaluate the safety and efficacy of nelotanserin in Lewy body dementia subjects experiencing visual hallucinations. Background: Nelotanserin is a selective 5HT2A receptor inverse…Hippocampal iron deposition in Parkinson disease and Parkinson disease with dementia/Lewy body dementia: quantitative susceptibility mapping assessments
Objective: We compared quantitative susceptibility mapping (QSM) values in the hippocampi among patients with Parkinson disease (PD) and PD with dementia (PDD)/ Lewy body dementia…
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