A Study of Microglial Metabolism in Neuroinflammation
Objective: Targeting of microglial metabolism may be a potential therapeutic option for diseases such as PD [Parkinson’s Disease] and LBD [Lewy Body Dementia]. To establish…Introduction of an Assessment Toolkit Increases the Rate of DLB Diagnosis
Objective: To assess whether diagnostic rates of both Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) could be increased by the introduction of…Diagnosing Dementia with Lewy Bodies – Characterizing the prevalence and underlying relationships between core and supportive clinical features
Objective: To characterize the interrelationship between core and supportive features of Dementia with Lewy Bodies, and identify optimal methods for their detection to inform better…Synaptic function in Parkinson’s disease associated with GBA mutations
Objective: To investigate the pathological substrate of impaired cognition in Parkinson’s disease (PD) associated with glucocerebrosidase (GBA) mutation. Background: Mutations in glucocerebrosidase gene (GBA), originally…Prodromal symptoms in clinically diagnosed dementia with Lewy bodies stratified by Lewy body pathology on autopsy
Objective: Compare prodromal neuropsychiatric, sleep, and motor symptoms in patients clinically diagnosed with dementia with Lewy bodies (DLB) with and without Lewy body pathology on…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…Functional connectivity and microstructural alterations in regions of synaptic density loss in DLB and PDD
Objective: We aimed to investigate whether functional connectivity and white matter integrity is altered in regions exhibiting reduced synaptic density, as measured by [11C]UCB-J-PET,in Dementia with…A Lewy body disease of widely confirmed Lewy bodies in the cerebral cortexes including the occipital lobe without pathological changes in the hippocampal CA2/3 region
Objective: We present Lewy body disease (LBD) showing unique neuropathological findings which are widely recognized Lewy bodies (LBs) in the cerebral cortexes including the occipital…Visual hallucinations in Lewy Body Disease are characterised by impaired sensory integration
Objective: To test whether increased reliance on prior knowledge is associated with visual hallucinations in Lewy Body Disease (LBD: Parkinson’s disease and Dementia with Lewy…Increased lysosphingolipids levels in blood of patients with multiple system atrophy
Objective: To estimate activity of lysosomal enzymes and lysosphingolipids concentration in dry blood spot of patients with synuleinopathies: Parkinson’s disease (PD), dementia with Lewy bodies…
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