Utilization of Skin Punch Biopsy for the Diagnosis of Alpha-synucleinopathy in Clinical Practice
Objective: To understand the use of skin punch biopsies for diagnosis and management of α-synucleinopathy within a large medical system. Background: Skin punch biopsy has…Predictors of Death within 6 Months in Individuals with Dementia with Lewy Bodies
Objective: To assess predictors of death in the subsequent 6 months in dementia with Lewy bodies (DLB). Background: Individuals with DLB commonly die of disease-related…Cardiovascular Associations of Cortical Lewy Bodies in the Oldest Old: The 90+ study
Objective: To identify potential risk factors for cortical Lewy Bodies (CLB) in the oldest-old (> 90 years old), we investigated if cardiovascular medical histories, medication…A Randomized, Double-blind, Phase 2a Clinical Trial to Study the Efficacy and Safety of Lamotrigine for Treatment of Patients with Dementia with Lewy Bodies
Objective: This proof-of-concept clinical trial will test the efficacy and safety of lamotrigine compared to placebo in patients with dementia with Lewy bodies (DLB). Background:…Assessing the Accuracy of Clinical Diagnostic Criteria of Lewy Body Dementia for Detection of Lewy Body Disease in the Oldest-Old: The 90+ Study
Objective: To examine if Lewy Body dementia (LBD) clinical diagnostic criteria will be less accurate for detecting Lewy Body Disease (the pathological diagnosis) in the oldest-old…Exploring the Therapeutic Target for Lewy Body Disease using gba1 Knock-out Medaka
Objective: This study was performed to explore the therapeutic target for Lewy body disease. Background: Lewy body disease (LBD), including Parkinson's disease and diffuse Lewy…Accuracy of Clinical features for Substantia Nigra Hypopigmentation and Cortical Lewy Body Presence in the Oldest-Old: The 90+ Study
Objective: To improve clinical diagnostic accuracy of Lewy Body Dementia (LBD), we assessed if frontal release signs are a useful screening tool for cortical Lewy…Diffusion MRI and Machine Learning Distinguish Alzheimer’s Disease and Dementia with Lewy Bodies
Objective: This study reports recent updates in the development of a support vector machine learning model to discriminate between dementia variants (i.e., Alzheimer’s disease (AD)…Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies
Objective: We examined the association between environmental phthalates (PAEs) exposure and gut microbiota and metabolome in dementia with Lewy bodies (DLB). Background: Alongside genetic factors,…The dementia with Lewy bodies related metabolic brain pattern (DLBRP) – a multicentric validation
Objective: Dementia with Lewy bodies-related pattern (DLBRP) has been identified from the FDG PET brain imaging of DLB patients and healthy controls previously. A multicentric…
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