Transcriptomic and Proteomic Profiling for Effective Deep Brain Stimulation in Parkinson’s Disease
Objective: To determine whether transcriptomic and proteomic changes predict better motor outcomes after deep brain stimulation (DBS) surgery in Parkinson’s disease (PD). Background: DBS is…Unveiling the Long-term Impact of Unilateral Vim DBS in Essential Tremor
Objective: Our aim is to evaluate the long-term benefit of unilateral VIM DBS. Background: Essential tremor (ET) is the most common movement disorder, and in…Understanding the Neurochemical Basis of STN and GPi-DBS: A Human Microdialysis Study
Objective: Analyze the extracellular concentrations of GABA and glutamate in response to acute electrical stimulation during DBS surgery using samples obtained from STN, thalamus, GPi…Deposition of phosphorylated TDP-43 around the tip of deep brain stimulation leads
Objective: The objective of this study is to investigate the depositions of abnormal proteins, including phosphorylated tau (p-tau) and phosphorylated transactivation response DNA-binding protein of…Effect of Target Selection on Mood, Pain, and Medications after DBS in PD
Objective: To describe the association between medication adjustments with mood and pain following bilateral deep brain stimulation (DBS) in Parkinson’s disease (PD). Background: Depression, anxiety,…Image-guided Programming versus Conventional Programming in Deep Brain Stimulation: Comparative Study of a Parkinson’s Disease Cohort and Subthalamic Neurostimulation
Objective: To compare the results of a Parkinson’s disease (PD) cohort submitted to subthalamic deep brain stimulation (STN-DBS) with image-guided programming (IGP) and conventional programming…Bilateral Deep Brain Stimulation in Subthalamic Nucleus versus Globus Pallidus Internus for refractory dystonia
Objective: Evaluate the effects of bilateral Deep Brain Stimulation (DBS) in Subthalamic Nucleus (STN) versus Globus Pallidus Internus (GPi) for patients with refractory dystonia. Background:…Real-Time Removal of Stimulus Artifact for Closed-Loop Deep Brain Stimulation by Synchronized Sample-And-Hold Artifact Blanking (SSAB): Verification in Animal Model
Objective: To develop and validate a real-time stimulus artifact removal analog front-end (AFE) by synchronized sample-and-hold artifact blanking (SSAB) technique with the Parkinsonian minipig model…Differentiating the Local Field Potential Oscillations in Low and Beta Range in Parkinson`s and Dystonic Movement Disorder
Objective: To framework the novel data of subcortical oscillations in Parkinson`s and dystonic patients for the comparison of local field oscillatory (low, beta) influence amongst…Personality of Parkinson’s disease patients may influence the development and evolution of non-motor fluctuations
Objective: to evaluate the impact of personality on non-motor fluctuations (NMFs) in Parkinson’s disease (PD) and on NMFs evolution after dopaminergic treatments or deep brain…
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