Quantifying reinforcement learning deficits in early stage Parkinson’s patients using a strategic decision-making task
Objective: 1.Characterize deficits in reinforcement learning processes in PD during a strategic game analogous to Rock-Paper-Scissors (RPS). 2.Examine the effects of dopaminergic (DA) treatment on…Cognitive function and impulsive-compulsive behaviors in Parkinson’s disease motor subtypes
Objective: To investigate the differences in cognitive function between tremor-dominant (TD) and akinetic-rigid (AR) subtypes of Parkinson disease (PD). Background: Higher rates of dementia, autonomic symptoms,…Cognitive impairment in early onset and familial Parkinson’s disease.
Objective: The Parkinson’s Families Project (PFP) is a large-scale cohort of early onset (symptom onset <45) and familial Parkinson’s disease (PD) patients. One aim of…Resting state functional connectivity in PD patients with and without Freezing of gait
Objective: To investigate resting state functional connectivity (rsFC) abnormalities in patients with Parkinson's disease (PD), either with (PD-FOG) or without freezing of gait (PD no-FOG). …Cognitive Mechanisms of Visual Dysfunction in Non-Demented PD Patients (PD-ND)
Objective: To conduct a comprehensive assessment of visual processing in PD-ND, including tests of low-level vision sensitive to retinal pathology, high-level object/spatial vision reflecting ventral/dorsal…Cognitive effects of GPi versus STN deep brain stimulation in Parkinson’s Disease: experience with patients with moderate cognitive impairment
Objective: To compare the cognitive effects of GPi versus STN deep brain stimulation for PD in patients with moderate cognitive impairment. Background: Patients with moderate…Autosomal Dominant Spinocerebellar Ataxia Secondary to CACNA1G in a Patient of German Ancestry
Objective: We describe the case of a male patient of German ancestry with SCA 42. Background: Hereditary spinocerebellar ataxia (SCA) describes a heterogeneous group of…Validation of a performance-based assessment of functional ability related to cognition in Parkinson’s disease
Objective: Validate the University of California San Diego Performance-Based Skills Assessment (UPSA) in Parkinson's disease (PD) Background: Diagnostic criteria for PD dementia (PDD) require significant…Domain-specific impact of cerebral white matter hyperintensities on Parkinson’s disease cognitive functioning
Objective: In this study, we investigate the relationship between white matter hyperintensities (WMH) and Parkinson's disease (PD) cognitive impairment using a comprehensive neuropsychological battery with…Use of latent class analysis and growth mixture modeling to examine longitudinal neurocognitive trajectories in non-demented Parkinson’s disease
Objective: Examine the utility of latent class analysis (LCA) and growth mixture modeling (GMM) to elucidate cognitive phenotypes and longitudinal trajectories of cognitive change in…
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