Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…Hyposmia as a biomarker in patients with Parkinson’s disease and atypical Parkinsonism
Objective: To investigate neural correlates associated with olfactory dysfunction using fMRI and EEG in Parkinsonism. Background: Patients with Parkinsonism experience non-motor symptoms during the onset…Parkinson’s Disease patients with diplopia exhibit visuospatial and visuoperceptive impairment
Objective: In this study, we investigated Parkinson’s disease (PD) patients with and without diplopia using motor and non-motor assessments, including detailed neuropsychological testing. We hypothesized…SYNGAP1-related intellectual disability with ataxia and late onset of epileptic seizures
Objective: To characterize seizures in a patient with SYNGAP1 mutation and the efficacy of antiepileptic drugs (AEDs). Background: SYNGAP1-related intellectual disability is characterized by developmental…Low Educational Level and Wilson’s disease: A direct path to cognitive decline
Objective: To assess cognitive profile of Wilson's Disease (WD) patients in a single tertiary Movement Disorders center in Fortaleza, Ceará, Brazil. Background: WD is an autosomal recessive disorder…Preclinical pharmacology and early clinical development of dopamine D1 positive allosteric modulators (D1PAMs) with therapeutic potential for neuropsychiatric disorders
Objective: The objective was to characterize novel dopamine D1PAMs pre-clinically in behavioral and neurochemical models and in phase 1 human studies in healthy volunteers and…The dual cognitive syndrome in Parkinson’s disease: volumetric, morphological and tractometric features
Objective: To assess volumetric, morphological and tractometric features associated with the fronto-striatal and posterior cortical cognitive profiles in Parkinson’s Disease (PD) Background: The dual syndrome…Predicting dementia in the first 6 years of Parkinson’s disease in the ICICLE-PD cohort
Objective: To determine which baseline cognitive tests in newly diagnosed participants with Parkinson’s disease (PD) predict conversion to dementia (PDD) within six years. Background: Cognitive…Exploring the role of the retrograde procedural memory in PD in the Luxembourg Parkinson’s Disease Study
Objective: Deepening knowledge of retrograde procedural memory (RPM) in typical Parkinson’s Disease (PD) patients to demonstrate that RPM is impaired in patients with PD. Background:…Candidate plasma miRNAs and EV protein as novel biomarkers in Parkinson’s disease patients with cognitive impairment and dementia
Objective: To determine the diagnostic value of circulating miRNAs and the extracellular vesicle proteins for early detection of patients with Parkinson’s disease and mild cognitive…
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