MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Chorea (also see specific diagnoses, Huntingtons disease, etc): Pathophysiology"

  • MDS Virtual Congress 2021

    Evaluation of CSF Assay usability for Huntington’s Disease (HD) Clinical Studies (mHTT, tHTT and NFL in HDClarity)

    D. Langbehn, D. Macdonald, C. Sampaio, A G. Ehrhardt (Iowa City, USA)

    Objective: Evaluate clinical utility of candidate biomarker assays for HD studies. Background: Multiple clinical trials targeting the lowering of huntingtin (HTT) are underway or planned.…
  • MDS Virtual Congress 2020

    A Case of Disabling Orofacial Dyskinesias Caused by Lupus Anticoagulant

    K. Colletta, S. Kletzel (Hines, IL, USA)

    Objective: We describe a 93-year-old man with subacute, progressive onset of disabling orofacial dyskinesias (OD), found to have positive lupus anticoagulant (LA) and anti-beta2-glycoprotein IgA…
  • MDS Virtual Congress 2020

    Discharge rate dependency of bursting of pallidal neurons underlying choreic movements

    T. Hashimoto, T. Goto, K. Yoshida, L. Johnson, J. Vitek (Matsumoto, Japan)

    Objective: To investigate the physiological mechanisms of neurons in the basal ganglia motor circuit underlying choreic movements. Background: Synchronized burst discharges and the low discharge…
  • MDS Virtual Congress 2020

    Cytokines and Brain Specific Antibodies in Experimental Cellular and Molecular Treatment of Huntington’s Diseases

    D. Labunskiy, S. Kiryukhina, V. Podsevatkin (Saransk, Russian Federation)

    Objective: Huntington’s Disease (HD) is a severe neurodegenerative disorder main pathogenic factor is CAG repeats in a suffered patients genome. Experimental therapy on the model…
  • MDS Virtual Congress 2020

    Longitudinal dynamics of mutant huntingtin and neurofilament light in Huntington’s disease: the prospective HD-CSF study

    F. Rodrigues, L. Byrne, R. Tortelli, E. Johnson, P. Wijeratne, M. Arridge, E. De Vita, D. Alexander, S. Tabrizi, S. Schobel, R. Scahill, A. Heslegrave, H. Zetterberg, E. Wild (London, United Kingdom)

    Objective: To present the mutant huntingtin (mHTT) and neurofilament light (NfL) findings from the two-year prospective longitudinal HD-CSF study, in which an 80-participant cohort of…
  • MDS Virtual Congress 2020

    Evaluation of Cortical Excitability in Huntington’s Disease and Parkinson’s Disease

    N. Togashi, M. Hamada, Y. Shirota, T. Toda, K. Nishiyama, K. Hasegwa (Sagamihara, Japan)

    Objective: To evaluate the cortical excitability difference in Huntington's disease (HD) and Parkinson's disease (PD) using paired-pulse transcranial magnetic stimulation (TMS). Background: TMS is useful…
  • MDS Virtual Congress 2020

    The roles of Huntingtin Associated Protein 40 in Huntingtin functions and Huntington’s disease pathogenesis

    S. Xu, G. Li, X. Ye, L. Ye, Z. Xu, E. Furr Stimming, S. Zhang (Houston, TX, USA)

    Objective: Huntington’s disease (HD) is caused by an abnormal expansion of a glutamine tract (polyQ) in huntingtin (HTT), a large scaffold protein with numerous reported…
  • 2019 International Congress

    Multimodal characterization of the visual network in Huntington’s disease

    O. Odish, S. Gregory, I. Mayer, J.. Mills, E. Johnson, R. Scahill, J. Rothwell, G. Rees, J. Long, S. Tabrizi, R. Roos, M. Orth (Leiden, Netherlands)

    Objective: To examine the relationship between structural organization, functional processing and task performance of the visual system in a cohort of Huntington’s disease (HD) gene-mutation…
  • 2019 International Congress

    Factors underlying reduced aerobic capacity in Huntington disease

    A. Rao, S. Norris, J. Montes, P. Wasserman, K. Marder (New York, NY, USA)

    Objective: Examine factors underlying aerobic capacity in prodromal and manifest Huntington disease (HD) and matched controls Background: HD results in motor impairments, weight loss, muscle…
  • 2019 International Congress

    Changes in GABAergic transmission of striatal neurons in presymptomatic Huntington’s Disease

    M. Treven, F. Zirpel, I. Mody (Vienna, Austria)

    Objective: To determine whether parameters of synaptic and extrasynaptic GABAergic inhibition of striatal projection neurons are altered in presymptomatic BACHD mice. Background: One attractive early…
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