Density of metabotropic glutamate receptors subtype 1 in de novo patients with Parkinson’s disease using 11C-ITMM PET
Objective: To investigate the mapping of metabotropic glutamate receptor subtype 1 (mGluR1) in elderly normal and de novo patients with Parkinson's disease (PD) using N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C…An open label trial to test the modulation of cerebellar motor pathways in primary orthostatic tremor using rTMS and fMRI
Objective: In patients with primary orthostatic tremor (OT), we assessed how functional impairment, electrophysiological measures of tremor and long-range connection between the cerebellum and the…Impaired cerebellum to motor cortex associative plasticity in Parkinson’s disease
Objective: To compare the corticocortical paired associative stimulation (PAS)-induced spike-timing dependent plasticity (STDP)-like plasticity between Parkinson's disease (PD) and healthy elder subjects. Background: Patients with…Structural and functional signature of primary orthostatic tremor
Objective: (1) We aimed to characterize, in primary orthostatic tremor (OT), the structural and functional defects in the cerebellar motor pathways; (2) We correlated the…Neural substrates of excessive daytime sleepiness in early drug naïve Parkinson’s disease: A resting state functional MRI study
Objective: We aimed to improve our understanding of the neuropathology of excessive daytime sleepiness (EDS) in Parkinson's disease (PD). Background: EDS is a common non-motor…Olfaction analysis in spinocerebellar ataxia type 10 and type 3 comparing with healthy controls and PD
Objective: To Analyse olfaction in spinocerebellar ataxia type 10 and type 3. Background: The main clinical manifestations of spinocerebellar ataxias (SCA) result from the involvement…Disruption of cerebellar connectivity in cervical dystonia
Objective: To evaluate the position of cerebellum in the pathophysiology of cervical dystonia by assessing the differences of cerebellar connectivity when comparing normal subjects and…Modelling spinocerebellar ataxia 15 with iPS cell derived neurons
Objective: Here we set out to study the cellular pathology of ITPR1-deletions underlying SCA15 in a human model of iPSC-derived cortical neurons. Background: Spinocerebellar Ataxia…Symptoms of dystonia in a mouse with mutation in Lamb1
Objective: A mouse model that exhibits symptoms appropriate to dystonia will allow investigation underlying circuit abnormalities. Here we tested two hypotheses with the lamb1t mouse:…Impaired eye voice coordination in spinocerebellar degeneration while reading aloud
Objective: In order to elucidate the cause of the impaired reading performance. Background: Deficit in reading performance in patients with spinocerebellar degeneration (SCD) has been…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.