MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Cell death"

  • 2016 International Congress

    Differential vulnerability to α-synuclein pathology among neuronal subpopulations

    E. Luna, D.M. Riddle, V.M.Y. Lee, K.C. Luk (Philadelphia, PA, USA)

    Objective: To identify the cell death pathway(s) activated by α-synuclein (α-syn) pathology in an in vitro model of Lewy pathology and determine if neuronal subpopulations…
  • 2016 International Congress

    ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

    T. Hasegawa, R. Oshima, K. Tamai, N. Sugeno, A. Kikuchi, J. Kobayashi, S. Yoshida, A. Takeda, N. Tanaka, M. Aoki (Sendai, Japan)

    Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…
  • 2016 International Congress

    CSF inflammatory and cell death biomarkers in Huntington’s disease – An exploratory cross-sectional study

    F.B. Rodrigues, L. Byrne, S.J. Tabrizi, H. Zetterberg, E. Wild (London, United Kingdom)

    Objective: This exploratory work intended to study general inflammatory cytokines, microglial activation markers, and neuronal cell death markers in the cerebrospinal fluid (CSF) of HD…
  • 2016 International Congress

    Diverse effects of alpha-synuclein fibrils on various neuron cell lines, using different buffers

    F. Aliakbari, D. Morshedi, A.A. Shabani, H. Mohammad Beigi, A. Tayaranian Marvian, P. Shariati, S.A. Shojaosadati, A.A. Saboury (Semnan, Islamic Republic of Iran)

    Objective: To investigate the neurotoxic properties of alpha-synuclein (α-Syn) aggregation in different buffers including PBS, SBF and Tris on altered cell lines, SHSY5Y, SK-N-MC and…
  • 2016 International Congress

    Autophagic modulation by rosuvastatin prevent rotenone induced neurotoxicity as an in vitro model of Parkinson’s disease

    W. Jang (Gangneung, Korea)

    Objective: We investigated effects of statin on autophagy markers and evaluated the neuroprotective effect of rosuvastatin from rotenone induced neurotoxicity. Background: Recently, autophagy pathway is…
  • 2016 International Congress

    Investigation into the genetic etiology in South African Parkinson’s disease patients

    G. Borrageiro, L. Van den Heuvel, S.M.J. Hemmings, S. Seedat, S. Bardien (Cape Town, South Africa)

    Objective: To investigate the genetic etiology in a group of South Africa Parkinson's disease (PD) patients. Background: The genetic etiology of PD is complex and…
  • 2016 International Congress

    Protective effects of ATP13A2 in Parkinson’s disease models

    S. Martin, S. van Veen, J. Zielich, T. Holemans, C. van den Haute, V. Beakelandt, P. Agostinis, P. Vangheluwe (Leuven, Belgium)

    Objective: Decipher the role of ATP13A2 in Parkinson's disease. Background: ATP13A2 is a lysosomal P-type ATPase with significant implications in Parkinson's disease (PD). Little is…
  • 2016 International Congress

    Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats

    S. Bido, L. Arcuri, M. Helly, R. Fan, K. Tieu, E. Bezard (Bordeaux, France)

    Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…
  • 2016 International Congress

    Cellular senescence induced by paraquat drives neuropathology associated with Parkinson’s disease

    S.J. Chinta, G. Woods, M. Demaria, J. Campisi, J.K. Andersen (Novato, CA, USA)

    Objective: To understand the role of cellular senescence in brain aging and neurodegeneration in Parkinson's disease models. Background: Although cellular senescence has been causally linked…
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