Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Investigation into the genetic etiology in South African Parkinson’s disease patients
Objective: To investigate the genetic etiology in a group of South Africa Parkinson's disease (PD) patients. Background: The genetic etiology of PD is complex and…Protective effects of ATP13A2 in Parkinson’s disease models
Objective: Decipher the role of ATP13A2 in Parkinson's disease. Background: ATP13A2 is a lysosomal P-type ATPase with significant implications in Parkinson's disease (PD). Little is…Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…Cellular senescence induced by paraquat drives neuropathology associated with Parkinson’s disease
Objective: To understand the role of cellular senescence in brain aging and neurodegeneration in Parkinson's disease models. Background: Although cellular senescence has been causally linked…Lewy body extracts from Parkinson’s disease brains as models for high-throughput screens of neurotoxicity and α-synuclein spreading from cell-to-cell
Objective: To validate the effect of Lewy body extracts from Parkinson's disease (PD) brains in high-throughput screens of neurotoxicity and the α-synuclein (α-syn) spreading from…Piper longum L. alkaloids inhibit lipopolysaccharide-stimulated microglial activation and protect nigral dopaminergic neurons
Objective: The ethanol-extracted alkaloids from the dry seeds of Piper longum L. (PLL) (family Piperaceae) PLA contain numerous compounds. We evaluate the potential of PLA…Characteristics of the interaction between different toxic aggregated species of alpha-synuclein and cell membrane
Objective: To determine (1) the interaction rate of each toxic aggregated species of alpha-synuclein (α-Syn) with cell membrane compare to the monomeric form, (2) the…Differential vulnerability to α-synuclein pathology among neuronal subpopulations
Objective: To identify the cell death pathway(s) activated by α-synuclein (α-syn) pathology in an in vitro model of Lewy pathology and determine if neuronal subpopulations…ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways
Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.