Differential vulnerability to α-synuclein pathology among neuronal subpopulations
Objective: To identify the cell death pathway(s) activated by α-synuclein (α-syn) pathology in an in vitro model of Lewy pathology and determine if neuronal subpopulations…ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways
Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…CSF inflammatory and cell death biomarkers in Huntington’s disease – An exploratory cross-sectional study
Objective: This exploratory work intended to study general inflammatory cytokines, microglial activation markers, and neuronal cell death markers in the cerebrospinal fluid (CSF) of HD…Diverse effects of alpha-synuclein fibrils on various neuron cell lines, using different buffers
Objective: To investigate the neurotoxic properties of alpha-synuclein (α-Syn) aggregation in different buffers including PBS, SBF and Tris on altered cell lines, SHSY5Y, SK-N-MC and…Autophagic modulation by rosuvastatin prevent rotenone induced neurotoxicity as an in vitro model of Parkinson’s disease
Objective: We investigated effects of statin on autophagy markers and evaluated the neuroprotective effect of rosuvastatin from rotenone induced neurotoxicity. Background: Recently, autophagy pathway is…Investigation into the genetic etiology in South African Parkinson’s disease patients
Objective: To investigate the genetic etiology in a group of South Africa Parkinson's disease (PD) patients. Background: The genetic etiology of PD is complex and…Protective effects of ATP13A2 in Parkinson’s disease models
Objective: Decipher the role of ATP13A2 in Parkinson's disease. Background: ATP13A2 is a lysosomal P-type ATPase with significant implications in Parkinson's disease (PD). Little is…Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…Cellular senescence induced by paraquat drives neuropathology associated with Parkinson’s disease
Objective: To understand the role of cellular senescence in brain aging and neurodegeneration in Parkinson's disease models. Background: Although cellular senescence has been causally linked…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.