Mitochondrial phenotype related to the A30P alpha-synuclein mutation as a patient-derived cellular model of Parkinson’s disease
Objective: Our study aims to perform detailed phenotyping of the A30P alpha-synuclein familial case of PD, allowing to identify underlying mechanisms of the disease that…The Association between Infections and Parkinson Disease: A Systematic Review and Meta-analysis
Objective: Our study aimed to recapitulate and summarize the findings from the literature to provide an overview on the correlation between infection and PD. Background:…Expression of late cell cycle markers in Parkinson Disease and Lewy Body Dementia
Objective: The objective of this study is to determine the expression of late cell cycle markers in Parkinson Disease (PD) and Lewy Body Dementia (LBD) Background:…Cerebrospinal fluid biomarkers in Huntington’s disease – a longitudinal study
Objective: To validate the role of NFL as a marker of disease progression and to discover new biomarkers in HD. Background: Neurofilament light chain (NFL)…Mutant DNAJC13 modulates accumulation and toxicity of alpha-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease
Objective: The aim of this study is to investigate the effect of DNAJC13 mutation on the vesicle transport, α-synuclein (αSYN) distribution/catabolism, and neurodegeneration using a…Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition
Objective: In this study, we investigated the role of autophagy system in MANF-mediated neuroprotection against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. Background: Autophagy and apoptosis are commonly involved…Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Investigation into the genetic etiology in South African Parkinson’s disease patients
Objective: To investigate the genetic etiology in a group of South Africa Parkinson's disease (PD) patients. Background: The genetic etiology of PD is complex and…Protective effects of ATP13A2 in Parkinson’s disease models
Objective: Decipher the role of ATP13A2 in Parkinson's disease. Background: ATP13A2 is a lysosomal P-type ATPase with significant implications in Parkinson's disease (PD). Little is…Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.