Neuromelanin-MRI in REM sleep behaviour disorder predicts dopaminergic dysfunction and clinical risk of Parkinson’s disease
Objective: To determine whether neuromelanin-MRI signal changes in the substantia nigra and locus coeruleus in patients with REM sleep behaviour disorder (RBD) are predictive of…Severe Gliosis following PPN-DBS
Objective: Neuropathological investigation of tissue changes in a case with pedunculopontine nucleus (PPN) DBS placed to address axial Parkinson’s disease symptoms and freezing of gait.…Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the raphe nuclei
Objective: To investigate whether apathy is related to serotonin depletion in the raphe nuclei in patients with rapid eye movement sleep behaviour disorder (RBD), a…AAV-mediated human alpha synuclein overexpression in the locus coeruleus (LC) leads to a neuronal loss in the nucleus ambiguus of mouse.
Objective: To investigate the impact and temporal aspects of the neuronal loss in the LC neurons induced by alpha-synucleinopathy Background: In the Braak staging model…Targeted overexpression of A53T-alpha-synuclein induces progressive neurodegeneration and electrophysiological changes of noradrenergic locus coeruleus neurons – a preclinical model of Parkinson’s disease
Objective: In our present study, we developed a new mouse model to study the time dependent effects of cellular A53T-α-synuclein overexpression in the locus coeruleus,…Epilepsy and Cranial nerve affection in a Patient with Wilson’s disease and Intracranial developmental venous anomaly; A Case Report
Objective: 1.present unusual and rare clinical presentations in the disease spectrum2.study Intracranial developmental venous anomalies (DVAs) presentations both clinically and radiologically in Wilson’s disease and their…Towards Responsive Deep Brain Stimulation for Medically Refractory Freezing of Gait in Parkinson’s Disease
Objective: Medically refractory FoG presents an unmet and pressing need to develop novel therapeutic strategies. We seek to describe the electrophysiology of the pedunculopontine nucleus…Striatal and pedunculopontine nucleus diffusion tensor imaging in cervical dystonia
Objective: To characterize white matter integrity in the striatum and pedunculopontine nucleus (PPN) in patients with cervical dystonia using diffusion tensor imaging (DTI). Background: The…Gaze evoked blepharospasm
Objective: Herein we present a patient with asymmetric blepharospasm (BLS) evoked by upward gaze. Background: Essential BLS is a focal presentation of dystonia. However, brain…Cervical dystonia associated to Wallenberg syndrome
Objective: To describe, for the first time, a patient who developed cervical dystonia with signs and symptoms of a Wallenberg syndrome. Background: Secondary cervical dystonia…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.