Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Dysconnectivity of the Parafascicular Nucleus in Parkinson’s Disease
Objective: The present study aimed to investigate the functional alterations of the parafascicular nucleus (Pf) projections in Parkinson’s disease (PD) patients. Background: Recent animal model…Exome sequencing of 584 Chinese proband with brain calcification
Objective: The aim of this study is to evaluate the diagnostic value of whole exome sequencing in Chinese patients with brain calcification, and to provide exome sequencing-based insights into the genetic…Uremic encephalopathy (UE) mimicking acute bulbar stroke with progression from bradykinesia to choreic movements in a diabetic patient undergoing hemodialysis: A case report
Objective: To present a case of uremic striatopallidal syndrome manifested by both hypo-and hyperkinetic extrapyramidal movements. Background: UE is an uncommon neurologic complication encountered in…Diabetic striatopathy presenting without hyperkinetic movements
Objective: To demonstrate a case of Diabetic striatopathy presenting without hyperkinetic movements Background: Diabetic striatopathy is an uncommon neurological complication associated with poorly controlled Diabetes Mellitus…Huntingtonism and bilateral basal ganglia hypointensity in a male with an XK variant but no McLeod red cell phenotype
Objective: To report a novel variant of XK without the characteristic RBC phenotype Background: XK disease (previously called McLeod Syndrome) is a rare X-linked disorder…Spectrum of hyperkinetic movement disorders in a Tunisian Cohort: an observational study
Objective: Recall clinical situations of hyperkinetic movement disorders (HMD) in a Tunisian cohort. Background: HMD result from a dysfunction of the basal ganglia(BG) and are…Levodopa-induced dyskinesia and Huntington’s chorea: link to current motor control theories
Objective: Determine if there is a motor control hypothesis that could explain movement kinematics of Huntington’s disease (HD) chorea and Parkinson’s disease (PD) levodopa-induced dyskinesia…Alterations in Cortico-basal ganglia Directed Connectivity in Parkinsonism and during Therapeutic STN DBS
Objective: Characterize the changes in oscillatory activity and connectivity in the basal ganglia thalamocortical (BGTC) network after induction of parkinsonian and during therapeutic deep brain…Encoding of action plans and confidence in the human basal ganglia-thalamic circuit
Objective: The basal ganglia (BG) are known to play a vital role in action initiation and inhibition, studied with several simple behaviors in multiple species.…
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