Failure of model-based outcome monitoring in Parkinson’s Disease Apathy
Objective: To investigate the neural basis of apathy in Parkinson’s Disease (PD). Background: Apathy is a debilitating and poorly understood syndrome characterised by a reduction…Severe parkinsonism late-onset in Wilson’s disease without typical basal ganglia involvement
Objective: Wilson's disease (WD) is an autosomal-recessive copper metabolism disease caused by ATP7B mutations. Background: Here we described an interesting case of WD. Method: A…Impaired Nt-acetylation and the Golgi, a new disease mechanism leading to autosomal recessive primary familial brain calcifications
Objective: To identify new disease-gene in unsolved autosomal recessive primary familial brain calcifications. Background: Primary familial brain calcification (PFBC) is characterized by calcium deposition in the brain,…Aging brain in Parkinson`s: A study through biomarkers
Objective: Ongoing research of electrophysiological characteristics in Parkinson`s do not take aging brain into account. So, we aim is to show impact of aging on…Structural analysis of the basal ganglia using ex vivo 7T MRI can differentiate frontotemporal lobar degeneration with TDP-43 vs tau accumulation.
Objective: Ex vivo 7T MRI can identify macrostructural changes in the basal ganglia that reflect underlying neuropathology, and can be used to differentiate between proteinopathies…Patterns of subthalamic synchronized oscillatory activity associated with parkinsonian subtypes
Objective: To explore whether patterns of synchronized subthalamic oscillatory neurons are involved in generating parkinsonian subtypes. Background: The pathophysiology for parkinsonian subtypes is unclear. Both…Amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): feasibility in the human
Objective: To assess the feasibility of continuously amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson's disease (PD) patients using a bidirectional, closed-loop brain…Role of the direct subthalamo-cerebellar tract in memory and learning: Implications for the pathophysiology of late-stage Parkinson’s Disease
Objective: To study the role of the recently identified direct subcortical cerebellum basal ganglia (C-BG) network in the pathophysiology of Parkinson’s Disease (PD). Background: Even…Increased alpha power in basal ganglia and thalamus following levodopa administration in a dystonic young adult
Objective: To evaluate effects of acute levodopa administration on frequency content of intracranial local field potentials in a dystonic young adult. Background: Levodopa is the…Automatic assessment of tic expression using selfie-video
Objective: To create an automatic objective measure for quantifying tic expression and modulation in natural behavioral settings. Background: Tourette syndrome (TS) is characterized by the…
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