Mechanisms of sub-anesthetic ketamine infusions to reduce L-DOPA-induced dyskinesia: effects on striatal mTOR signaling and beta band oscillations in striatum and motor cortex
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesia (LID). Background: We have published preclinical evidence and patient case…Dynamics of subthalamic nucleus beta bursts in Parkinson’s disease during ON and OFF dopaminergic state
Objective: To investigate the dynamics of beta bursts in subthalamic nucleus (STN) local field potentials (LFP) in patients with Parkinson’s disease (PD) before and after…Dopamine replacement influences on postural motor learning in Parkinson disease
Objective: To determine if i) dopamine replacement affects general and sequence specific learning of a postural task in people with Parkinson disease (PD), and ii)…Reviewing the Clinical and Mutational Spectrum of SLC20A2 Mutations in Primary Familial Brain Calcification (PFBC) for MDSGene
Objective: Following the MDSGene protocol, we here present the clinical and mutational spectrum of SLC20A2 mutations, thereby adding the first gene found to be mutated…Subcortical involvement in phonological input processing: an electrophysiological registration study
Objective: The current study applied direct electrophysiological registration of the local field potential activity in the thalamus, subthalamic nucleus (STN) and the pedunculopontine nucleus (PPN)…Firing rate and proportion of subthalamic oscillatory neurons increase associated with more advanced Parkinson’s Disease
Objective: To explore whether neuronal firing rate and proportion of oscillatory neuronal activity in the subthalamic nucleus (STN) is associated with severity in patients with…Subcortical involvement in body and mental action processing: an electrophysiological registration study
Objective: The current research project focusses on the electrophysiological registration of semantics (body versus mental action verbs) within the thalamus, subthalamic nucleus (STN) and the…A case of thalamic malignant glioma formation in a patient with STN-DBS for Parkinson’s disease
Objective: We present a case of development of malignant glioma (glioblastoma multiforme) in the area adjacent to electrostimulation zone in a patient with chronic STN-DBS,…Long term recordings of subthalamic ocillatory activity in patients with Parkinson’s disease
Objective: The aim of this study was to investigate the stability of beta oscillations (13 - 30 Hz) in the subthalamic nucleus (STN) of patients…In-vivo free-water imaging and functional connectivity in a knock-in mouse model of DYT1 dystonia
Objective: To examine in-vivo functional connectivity and free-water diffusion imaging in dystonic mutant Tor1a knock-in (DYT1) and wild-type (WT) control mice. We test the hypothesis…
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