Population Pharmacokinetics and Pharmacodynamics of Ampreloxetine (TD-9855) in Patients with Neurogenic Orthostatic Hypotension (nOH)
Objective: To characterize the Phase 2 pharmacokinetics (PK) and pharmacodynamics (PD) of ampreloxetine in patients with nOH and provide dosing recommendations for special populations in…Autonomic dysfunction in early Parkinson’s disease: a prospective study
Objective: To define prevalence, severity, and predictors of dysautonomia symptoms in patients with Parkinson's disease (PD) recruited at the Hoehn and Yahr stage 1 prospectively followed for three years.…Differences in correlation with cardiac sympathetic denervation between depression and anhedonia in drug naïve Parkinson disease patients
Objective: To compare the correlation with some assessments of DAT scan and myocardial MIBG scintigraphy between depression and anhedonia in drug naive Parkinson's Disease (PD)…Decreased baroreflex sensitivity in Parkinson’s disease is associated with orthostatic hypotension
Objective: To compare the baroreflex sensitivity (BRS) of Parkinson’s disease patients with those of an age-matched control population, and to determine BRS association with blood pressure,…Dry eye in Parkinson’s disease: symptoms, consequences and treatment options
Objective: Dry eye is a common side effect of PD/PSP and easily manageable, yet its occurrence and debilitating ramifications are often unrecognized. The aim of…Characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease
Objective: To evaluate the characteristics of lower gastrointestinal tract dysfunction in patients with Parkinson disease (PD). Background: Lower gastrointestinal tract dysfunction is common in patients…Abnormal respiratory rate and patterns in MSA
Objective: To evaluate respiratory rate and patterns in patients with Multiple Systems Atrophy (MSA). Background: One of the primary clinical features of multiple system atrophy…Cardiovascular autonomic function and MCI in Parkinson’s disease
Objective: To evaluate the association between cardiovascular dysautonomia and Mild Cognitive Impairment (MCI) in Parkinson’s Disease (PD) patients. Background: Dysautonomic dysfunction and cognitive impairment represent…Incidence of drooling in Parkinson’s Disease and Impact on Quality of Life
Objective: The project aimed to determine the frequency and severity of drooling in the Parkinson’s Disease (PD) population in Cardiff & the Vale Health-board through…Frequency of Cardiovascular Abnormalities in Mexican Patients with Early Parkinson´s Disease
Objective: To determine frequency of cardiovascular abnormalities and autonomic dysfunction in the early course of Parkinson's disease Background: Parkinson´s disease (PD) is a neurodegenerative disease…
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