The Parkinson’s Impact Project: A Multimodal Longitudinal Study of Disease Development and Progression at the 23andMe Research Institute
Objective: Characterize the interactions between lifestyle, environmental, and genetic exposures on susceptibility to Parkinson’s disease (PD) and progression rates through a scalable remote web-based multimodal…Standardized Autonomic and Movement Assessment in Mexican Patients with Undetermined and Degenerative Progressive Parkinsonism: A Single-Center Experience
Objective: We proposed a unified and standard autonomic and movement evaluation to discriminate patients' Parkinsonism related to synucleinopathies from other conditions during a clinical office…Diagnosing Prodromal Synucleinopathies – What is the Role of Cardiac MIBG Scintigraphy?
Objective: We aimed to characterize cardiac MIBG uptake patterns in patients with an initial diagnosis of PAF (iPAF) and assess their role as a prognostic…Cerebellar peduncle microstructure and autonomic dysfunction in Parkinson’s disease
Objective: To investigate whether cerebellar peduncle microstructure is associated with autonomic dysfunction in Parkinson’s disease (PD). Background: Autonomic dysfunction is a common and disabling non-motor…Sudomotor Dysfunction in Patients With Normal and Abnormal Cardiac MIBG
Objective: We examined the pattern of sweat loss in patients with normal versus abnormal MIBG and considered the implications of this in predicting phenoconversion trajectory.…The Unholy Marriage Between Ogilvie Syndrome and Parkinson’s Disease
Objective: To demonstrate the dynamic interplay between advanced Parkinson’s disease (PD)–related colonic dysmotility and acute colonic pseudo-obstruction (ACPO; Ogilvie syndrome) and to highlight practical red…A prospective single-center study investigating the utility of supportive features in the diagnosis of multiple system atrophy with predominant cerebellar ataxia
Objective: The present study aimed to determine the utility of supportive motor and nonmotor features in differentiating multiple system atrophy (MSA) with predomainat cerebellar ataxia…Movement Disorder Phenotypes in Neuronal Antibody–Mediated Autoimmune Encephalitis
Objective: To characterize movement disorder phenotypes in neuronal antibody–mediated autoimmune encephalitis (AE) and assess associations with specific antibody subtypes. Background: Neuronal antibody–mediated AE is a…Pattern and progression of sudomotor dysfunction in alpha synucleinopathies
Objective: This study examined the distribution and longitudinal progression of sweat loss in patients with PAF. Background: Pure autonomic failure (PAF) is an alpha-synucleinopathy with…Structural validity, reliability, and minimally important differences for the SCOPA-AUT
Objective: To determine the structural validity, reliability, and minimally important difference values for the SCOPA-AUT. Background: Autonomic dysfunction is common in Parkinson’s disease (PD). A…
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