Therapies, Research Funding and Racial Diversity in Cerebellar Ataxia: A Systematic Review of the Literature
Objective: To understand the scope of clinical research in cerebellar ataxia by performing a systematic review of controlled clinical trials over the past 50 years,…Isolated ZIC4 antibody associated paraneoplastic cerebellar degeneration
Objective: Anti-ZIC4 antibodies have recently been associated with paraneoplastic cerebellar degeneration (PCD) and are usually associated with small cell carcinoma lung. However, most of the…Gene Expression Quantification to Assess Frataxin Replacement Therapies in Friedreich’s Ataxia
Objective: To identify genetic disease and efficacy markers for Friedreich’s ataxia (FRDA) Background: FRDA is a genetic disease caused by decreased expression of the mitochondrial…Leading Therapeutic Molecules Target Transcription Factors Binding to Repressor Region in FXN Gene
Objective: To investigate interactions of transcription factors (TFs) binding to repressor region located upstream to FXN gene with leading therapeutic molecules. Background: Low levels of…Tissue Frataxin Increases After Administration of CTI-1601, a Frataxin Replacement Therapy in Development for the Treatment of Friedreich’s Ataxia
Objective: To evaluate the pharmacodynamic (PD) and safety profiles of subcutaneous (SC) administration of multiple ascending doses of CTI-1601 in patients age ≥18 years with…Cerebellar bioenergetic depletion following ubiquinol supplementation in a patient with COQ8A-related ataxia
Objective: To non-invasively map the individual treatment response in a patient with COQ8A-related ataxia following coenzyme Q10 supplementation. Background: Primary coenzyme Q10 (CoQ10) deficiency is…The use of Virtual Reality to Assess the Quality of Life in Patients with Spinocerebellar Ataxia
Objective: To assess independence, confidence and balance for development daily activities in patients with SCAs, before and after rehabilitation with virtual reality (ViR). Background: Spinocerebellar…Balance rehabilitation with a virtual reality protocol for patients with hereditary spastic paraplegia: Protocol for a clinical trial
Objective: Determine benefits of vestibular rehabilitation involving virtual reality through the comparison of pre-intervention and post-intervention evaluations in individuals with hereditary spastic paraplegia. Background: Neurodegenerative…Beyond Parkinson’s disease: the use of standardized speech, physical and occupational therapies for PD in atypical parkinsonisms, other movement disorders and aging conditions
Objective: 1) Examine how speech, physical and occupational therapists are using evidence-based, Parkinson’s specific treatments (LSVT LOUD and LSVT BIG) in atypical parkinsonisms, other movement…Implementation of computer game technologies for patients with ataxia due to post-traumatic head injury: Randomized controlled trial
Objective: Up to 85 % of patients with post-traumatic brain injury suffer motor discoordination, ataxia and dyspraxia. The formation of the correct movement patterns, improved…
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