Dysregulated long non-coding RNA in Parkinson’s disease contributes to the apoptosis of dopaminergic neuron
Objective: The study aims to explore the expression profiles of lncRNA of PD patients and its roles to the pathogenesis of PD. Background: The molecular…Neuroprotective effect of Lemon oil on 6-OHDA-Induced Apoptosis in PC12 Cells through the ROS-NO Pathway
Objective: The objective of current investigation was to decipher e the neuroprotective effect of lemon oil (LO) on PC 12 cell lines by 6-hydroxydopamine (6-OHDA)…Risk of developing the Parkinson’s disease against the background of diabetes mellitus type 2.
Objective: To evaluate whether type 2 diabetes at baseline is a risk factor for Parkinson's disease. Background: Parkinson’s disease is a chronic disorder in which…Evaluation of nigral neuronal apoptosis during postnatal development and adulthood of mice strains with differential sensitivity to MPTP
Objective: Compare nigral neurons in C57BL/6J, CD-1 and their F1 crossbreds with respect to developmental apoptosis in the nigra during postnatal and to assess MPTP-induced…Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) -mediated ubiquitination attributed to localization of Mortalin to mitochondria
Objective: The pathogenic mechanism of UCHL1 in PD remains unclear. In this study, we aimed to investigate the role of UCHL1 in the pathogenesis of…Molecular mechanisms of GCH1-associated Parkinson’s disease
Objective: To unravel the molecular mechanisms by which loss of GCH1 function enhances the risk of Parkinson´s disease (PD). Background: Loss-of-function mutations in GCH1 are…Neuroprotective effect of exogenous melatonin on apoptosis of neuroadernergic neurons in a rat model of Parkinson’s disease
Objective: To investigate melatonin therapeutic potential effects in Parkinson’s disease. Background: Sleep disorders constitute major nonmotor features of Parkinson’s disease (PD) that have a substantial…Characterizing the Bcl-2 Associated Athanogene 5 Interactome
Objective: Characterizing the Bcl-2 Associated Athanogene 5 (BAG5) interactome will uncover the molecular pathways with which BAG5 associates and further elucidate its role in dopaminergic…Piper betle L. Attenuates 6-OHDA Induced Apoptosis in SH-SY5Y Cells and Neuronal Injury in Caenorhabditis elegans Parkinson’s Model
Objective: To explore the anti-apoptotic effects of Piper bitle leaf extract (PLE) on 6-OHDA induced cellular injury in human neuroblastoma cell SH-SY5Y. To analyse the neuroprotective…Neuroprotection of indole-derivative compound NC001-8 in Parkinson disease cell model by regulatory of NRF2 pathway
Objective: The goal of this study is to investigate the effects of indole-derivative compound NC001-8 on neuroprotection in PD disease cell model. Background: Parkinson’s disease…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.